Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 1699264..1699790 | Replicon | chromosome |
| Accession | NZ_CP070098 | ||
| Organism | Escherichia coli strain FDAARGOS_1370 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | I6L00_RS08735 | Protein ID | WP_000323025.1 |
| Coordinates | 1699264..1699551 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | I6L00_RS08740 | Protein ID | WP_000534858.1 |
| Coordinates | 1699551..1699790 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6L00_RS08690 (1694348) | 1694348..1694806 | - | 459 | WP_000526135.1 | IS200/IS605-like element IS200C family transposase | - |
| I6L00_RS08695 (1695257) | 1695257..1695472 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| I6L00_RS08700 (1695773) | 1695773..1695985 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| I6L00_RS08705 (1696040) | 1696040..1696129 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| I6L00_RS08710 (1696407) | 1696407..1697159 | - | 753 | WP_001047135.1 | antitermination protein | - |
| I6L00_RS08715 (1697173) | 1697173..1698222 | - | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| I6L00_RS08720 (1698224) | 1698224..1698502 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| I6L00_RS08725 (1698569) | 1698569..1698820 | - | 252 | WP_000980994.1 | protein Rem | - |
| I6L00_RS08730 (1699037) | 1699037..1699192 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| I6L00_RS08735 (1699264) | 1699264..1699551 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| I6L00_RS08740 (1699551) | 1699551..1699790 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| I6L00_RS08745 (1699815) | 1699815..1700120 | + | 306 | WP_001326990.1 | protein YdfV | - |
| I6L00_RS08750 (1700323) | 1700323..1700655 | + | 333 | WP_001301033.1 | FlxA-like family protein | - |
| I6L00_RS25820 (1701092) | 1701092..1701241 | - | 150 | WP_011443592.1 | protein YdfW | - |
| I6L00_RS08755 (1701362) | 1701362..1702384 | - | 1023 | Protein_1599 | ISNCY family transposase | - |
| I6L00_RS08760 (1702889) | 1702889..1703911 | - | 1023 | WP_000915483.1 | DUF4868 domain-containing protein | - |
| I6L00_RS08765 (1703914) | 1703914..1704528 | - | 615 | WP_001265627.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1655810..1714308 | 58498 | |
| - | flank | IS/Tn | - | - | 1694348..1694806 | 458 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T193081 WP_000323025.1 NZ_CP070098:c1699551-1699264 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T193081 NZ_CP092690:c1002724-1002197 [Salmonella enterica subsp. enterica serovar Thompson]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGCGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGCGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT193081 WP_000534858.1 NZ_CP070098:c1699790-1699551 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT193081 NZ_CP092690:c1003011-1002721 [Salmonella enterica subsp. enterica serovar Thompson]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGACTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGACTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|