Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 1071720..1072504 | Replicon | chromosome |
| Accession | NZ_CP070098 | ||
| Organism | Escherichia coli strain FDAARGOS_1370 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | V0T0H9 |
| Locus tag | I6L00_RS05545 | Protein ID | WP_000613626.1 |
| Coordinates | 1071720..1072214 (-) | Length | 165 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | L4JCW6 |
| Locus tag | I6L00_RS05550 | Protein ID | WP_001110447.1 |
| Coordinates | 1072211..1072504 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6L00_RS05525 (1066913) | 1066913..1068010 | + | 1098 | WP_000589326.1 | flagellar basal body P-ring protein FlgI | - |
| I6L00_RS05530 (1068010) | 1068010..1068951 | + | 942 | WP_001522863.1 | flagellar assembly peptidoglycan hydrolase FlgJ | - |
| I6L00_RS05535 (1069017) | 1069017..1070660 | + | 1644 | WP_001522865.1 | flagellar hook-associated protein FlgK | - |
| I6L00_RS05540 (1070672) | 1070672..1071625 | + | 954 | WP_001212768.1 | flagellar hook-associated protein FlgL | - |
| I6L00_RS05545 (1071720) | 1071720..1072214 | - | 495 | WP_000613626.1 | GNAT family N-acetyltransferase | Toxin |
| I6L00_RS05550 (1072211) | 1072211..1072504 | - | 294 | WP_001110447.1 | DUF1778 domain-containing protein | Antitoxin |
| I6L00_RS05555 (1072637) | 1072637..1075822 | - | 3186 | WP_001522867.1 | ribonuclease E | - |
| I6L00_RS05560 (1076395) | 1076395..1077354 | + | 960 | WP_023153797.1 | 23S rRNA pseudouridine(955/2504/2580) synthase RluC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 165 a.a. Molecular weight: 18084.00 Da Isoelectric Point: 8.2617
>T193073 WP_000613626.1 NZ_CP070098:c1072214-1071720 [Escherichia coli]
MIQAPEPLMARHQFTSFCSGVETMDNWLKQRALKNQLAGASRTFVSCDTYSNVLAYYSLASSAVETYVATGRFRRNMPEP
IPVVVLGRLAIDKSLQGQGIGRAMVRDAGLRVLQAAEVIGIRGMLVHALSDQAREFYLRVGFEPSPVDSMILMATLADLQ
ECLK
MIQAPEPLMARHQFTSFCSGVETMDNWLKQRALKNQLAGASRTFVSCDTYSNVLAYYSLASSAVETYVATGRFRRNMPEP
IPVVVLGRLAIDKSLQGQGIGRAMVRDAGLRVLQAAEVIGIRGMLVHALSDQAREFYLRVGFEPSPVDSMILMATLADLQ
ECLK
Download Length: 495 bp
>T193073 NZ_CP092686:c46494-45553 [Vibrio campbellii]
ATGAACACACTAAAACAACAGTTCCTTGAGGTTTCCGATGCGCTTGAGCTCGGAAACCCAGCCATTATTGAAAAAGATTA
CTGGGTCGTGGCTTTACTGGCTGAGCTAGCGAAAGTTTCTCCTGAGCATCATCAAATGGTGTTTTCTGGCGGCACTGCGT
TGGCGAAATCAAACGTTAAAATTCTAAGAATGTCGGAAGATGTGGATATAAAACTCATCCCCAACCCAGCATTTGATGAA
CTGAGCCGTGCGAGAAAGAAAGCCGCGAGAAAGGCATGTGTTAACGAGATTGAACAGGCGATCACTCGGTCAGAGCTATT
TACGGTTGAAGAGCGTTCTGTGCGAGATGAGTACCGCTACGTCGAGTTTGAACTTAAATACCCGCAGCAGTTTAGTCAAG
CGCCCTGCCTTCGCCCAATCATCAAGTTGGAGTTAATCGAAACCATTCCATTACTGGATGTGGAGTCGCGCAGCATTCAA
TCTCTGGTAGCAGAGTTGTACCAACAACCACAAGAAGTGAGTGCATTTGATTGCGTCTCTATCCATGCCACATTGGTTGA
AAAAATTATTTCAATGCTGCGCCGTACCATGTCGGTAAAACGCAATACGGAGCGAAACGATGATGTTGCTTTAGTTCGCC
ACATCTACGATGTGCACTGCATAACAAAGCTCGCAATGCCTGAACTCAACGGGGTTGTCGGCCTATTCAAAGCGGTTTTG
GAAGAAGATATTGCCCGCTTTGGCAATCAACATGCCGAGTTTGTTGCCAACCCCAAACAAGAGCTACAACTTGGCCTCAA
AGAGCTTGAGGAGAATCCAATTTTCCGCCAACGCTTTCAGGACTTTGTCACGCCAATGGTGTTTAACACCGAACCCCATG
ATTTTGATACCTGCTTTGCCTCATTTAAACGCATTGCAGCATCGCTAATTGAAAAAATTTAA
ATGAACACACTAAAACAACAGTTCCTTGAGGTTTCCGATGCGCTTGAGCTCGGAAACCCAGCCATTATTGAAAAAGATTA
CTGGGTCGTGGCTTTACTGGCTGAGCTAGCGAAAGTTTCTCCTGAGCATCATCAAATGGTGTTTTCTGGCGGCACTGCGT
TGGCGAAATCAAACGTTAAAATTCTAAGAATGTCGGAAGATGTGGATATAAAACTCATCCCCAACCCAGCATTTGATGAA
CTGAGCCGTGCGAGAAAGAAAGCCGCGAGAAAGGCATGTGTTAACGAGATTGAACAGGCGATCACTCGGTCAGAGCTATT
TACGGTTGAAGAGCGTTCTGTGCGAGATGAGTACCGCTACGTCGAGTTTGAACTTAAATACCCGCAGCAGTTTAGTCAAG
CGCCCTGCCTTCGCCCAATCATCAAGTTGGAGTTAATCGAAACCATTCCATTACTGGATGTGGAGTCGCGCAGCATTCAA
TCTCTGGTAGCAGAGTTGTACCAACAACCACAAGAAGTGAGTGCATTTGATTGCGTCTCTATCCATGCCACATTGGTTGA
AAAAATTATTTCAATGCTGCGCCGTACCATGTCGGTAAAACGCAATACGGAGCGAAACGATGATGTTGCTTTAGTTCGCC
ACATCTACGATGTGCACTGCATAACAAAGCTCGCAATGCCTGAACTCAACGGGGTTGTCGGCCTATTCAAAGCGGTTTTG
GAAGAAGATATTGCCCGCTTTGGCAATCAACATGCCGAGTTTGTTGCCAACCCCAAACAAGAGCTACAACTTGGCCTCAA
AGAGCTTGAGGAGAATCCAATTTTCCGCCAACGCTTTCAGGACTTTGTCACGCCAATGGTGTTTAACACCGAACCCCATG
ATTTTGATACCTGCTTTGCCTCATTTAAACGCATTGCAGCATCGCTAATTGAAAAAATTTAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 11109.69 Da Isoelectric Point: 10.5423
>AT193073 WP_001110447.1 NZ_CP070098:c1072504-1072211 [Escherichia coli]
MPAANNIPTRRESLNLRIKPAERDLIDRAAKARGKNRTEFVLEAARAAAEEALIEQRIFRIDSDDYQLFLNRLDQPPAPN
AALRKTMQTPAPWEQKK
MPAANNIPTRRESLNLRIKPAERDLIDRAAKARGKNRTEFVLEAARAAAEEALIEQRIFRIDSDDYQLFLNRLDQPPAPN
AALRKTMQTPAPWEQKK
Download Length: 294 bp
>AT193073 NZ_CP092686:c46900-46496 [Vibrio campbellii]
ATGACAGCAGTAGACCGCATTTGTCAAAAGATAAAGCGTTCAAGACGTTATGTATTTGAACGCAAAGACTTTGATGGATT
TGCAAGTTACGACCAAATAGGCCGGGCACTCAGACAGCTTGTGCAGCAAGGGGAACTAATGAAGCTTGGTTATGGTTTGT
ATACCAAAGCAAGAATCAATAGCCTCACAGGTAAGCCTATGCCCACCAATCCAGGTGGCACCGATGCCCTTATGCGAGAA
ATTCTTAAAATGAAAGGCGTTGATTTTGAGATGGATAGTCTATCGCTGCAAAGTCTTTCAGGCACGAGTACCCAAATTCC
ATCTTCTATTCAGTATTCATGGGACCCAAAACAGTTTAATCGCAAACTGGTGGTCGGGAGCCGTGTGCTGAACTTACCAA
GTTAG
ATGACAGCAGTAGACCGCATTTGTCAAAAGATAAAGCGTTCAAGACGTTATGTATTTGAACGCAAAGACTTTGATGGATT
TGCAAGTTACGACCAAATAGGCCGGGCACTCAGACAGCTTGTGCAGCAAGGGGAACTAATGAAGCTTGGTTATGGTTTGT
ATACCAAAGCAAGAATCAATAGCCTCACAGGTAAGCCTATGCCCACCAATCCAGGTGGCACCGATGCCCTTATGCGAGAA
ATTCTTAAAATGAAAGGCGTTGATTTTGAGATGGATAGTCTATCGCTGCAAAGTCTTTCAGGCACGAGTACCCAAATTCC
ATCTTCTATTCAGTATTCATGGGACCCAAAACAGTTTAATCGCAAACTGGTGGTCGGGAGCCGTGTGCTGAACTTACCAA
GTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|