Detailed information of TA system TA193056

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3893610..3895198
• Replicon: chromosome
• Accession: NZ_CP070092
• Organism: Klebsiella pneumoniae strain FDAARGOS_1316

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A486MZ73
• Locus tag: I6K46_RS18795
• Protein ID: WP_009485244.1
• Coordinates: 3893876..3895198 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: I6K46_RS18790
• Protein ID: WP_002904790.1
• Coordinates: 3893610..3893876 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K46_RS18765	3888760..3889683	+	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-
I6K46_RS18770	3889664..3890818	-	1155	WP_009485247.1	FAD-dependent urate hydroxylase HpxO	-
I6K46_RS18775	3891164..3892543	+	1380	WP_004184021.1	purine permease	-
I6K46_RS18780	3892521..3893021	+	501	WP_002904787.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
I6K46_RS18785	3893018..3893344	+	327	WP_009485245.1	hydroxyisourate hydrolase	-
I6K46_RS18790	3893610..3893876	+	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
I6K46_RS18795	3893876..3895198	+	1323	WP_009485244.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6K46_RS18800	3895215..3896507	-	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
I6K46_RS18805	3896649..3897653	-	1005	WP_009485243.1	type 1 fimbrial protein	-
I6K46_RS18810	3897641..3900142	-	2502	WP_009485242.1	fimbrial biogenesis outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	blaSHV-26	iroE / mgtC	3640456..4067625	427169

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49157.50 Da
• Isoelectric Point: 7.5062

>T193056 WP_009485244.1 NZ_CP070092:3893876-3895198 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPICEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T193056 NZ_CP092656:c5203272-5202988 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT193056 WP_002904790.1 NZ_CP070092:3893610-3893876 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT193056 NZ_CP092656:c5203504-5203262 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• AlphaFold DB: A0A486MZ73

Antitoxin

• AlphaFold DB: A0A0H3GXD8