Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 1684345..1686026 Replicon chromosome
Accession NZ_CP070092
Organism Klebsiella pneumoniae strain FDAARGOS_1316

Toxin (Protein)


Gene name mosT Uniprot ID J2XCI1
Locus tag I6K46_RS08120 Protein ID WP_004146663.1
Coordinates 1685109..1686026 (+) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag I6K46_RS08115 Protein ID WP_004177809.1
Coordinates 1684345..1685103 (+) Length 253 a.a.

Genomic Context


I6K46_RS08110I6K46_RS08115I6K46_RS08120I6K46_RS08100I6K46_RS08105I6K46_RS08125I6K46_RS08130I6K46_RS08135I6K46_RS08140
Location: 1683531..1684259 (729 bp)
Type: Others
Protein ID: WP_002885152.1
Location: 1684345..1685103 (759 bp)
Type: Antitoxin
Protein ID: WP_004177809.1
Location: 1685109..1686026 (918 bp)
Type: Toxin
Protein ID: WP_004146663.1
Location: 1679963..1680649 (687 bp)
Type: Others
Protein ID: WP_004151733.1
Location: 1681111..1683258 (2148 bp)
Type: Others
Protein ID: WP_012737173.1
Location: 1686151..1687158 (1008 bp)
Type: Others
Protein ID: WP_009484222.1
Location: 1687233..1688174 (942 bp)
Type: Others
Protein ID: WP_002885156.1
Location: 1688205..1689203 (999 bp)
Type: Others
Protein ID: WP_002885172.1
Location: 1689200..1690720 (1521 bp)
Type: Others
Protein ID: WP_004210021.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6K46_RS081001679963..1680649-687WP_004151733.1sel1 repeat family protein-
I6K46_RS081051681111..1683258-2148WP_012737173.1formate dehydrogenase H subunit alpha, selenocysteine-containing-
I6K46_RS081101683531..1684259+729WP_002885152.1response regulator transcription factor-
I6K46_RS081151684345..1685103+759WP_004177809.1type IV toxin-antitoxin system AbiEi family antitoxinAntitoxin
I6K46_RS081201685109..1686026+918WP_004146663.1nucleotidyl transferase AbiEii/AbiGii toxin family proteinToxin
I6K46_RS081251686151..1687158-1008WP_009484222.1carbohydrate kinase family protein-
I6K46_RS081301687233..1688174-942WP_002885156.1ABC transporter substrate-binding protein-
I6K46_RS081351688205..1689203-999WP_002885172.1ribose ABC transporter permease-
I6K46_RS081401689200..1690720-1521WP_004210021.1sugar ABC transporter ATP-binding protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 306 a.a.        Molecular weight: 34659.10 Da        Isoelectric Point: 5.4707

>T193052 WP_004146663.1 NZ_CP070092:1685109-1686026 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T193052 NZ_CP092656:1330946-1331356 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT193052 WP_004177809.1 NZ_CP070092:1684345-1685103 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT193052 NZ_CP092656:1330699-1330965 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBJ2XCI1


Antitoxin

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Source
ID
Structure
AlphaFold DBA6TH05

References