Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
Location | 1684345..1686026 | Replicon | chromosome |
Accession | NZ_CP070092 | ||
Organism | Klebsiella pneumoniae strain FDAARGOS_1316 |
Toxin (Protein)
Gene name | mosT | Uniprot ID | J2XCI1 |
Locus tag | I6K46_RS08120 | Protein ID | WP_004146663.1 |
Coordinates | 1685109..1686026 (+) | Length | 306 a.a. |
Antitoxin (Protein)
Gene name | mosA | Uniprot ID | A6TH05 |
Locus tag | I6K46_RS08115 | Protein ID | WP_004177809.1 |
Coordinates | 1684345..1685103 (+) | Length | 253 a.a. |
Genomic Context
Location: 1683531..1684259 (729 bp)
Type: Others
Protein ID: WP_002885152.1
Type: Others
Protein ID: WP_002885152.1
Location: 1684345..1685103 (759 bp)
Type: Antitoxin
Protein ID: WP_004177809.1
Type: Antitoxin
Protein ID: WP_004177809.1
Location: 1685109..1686026 (918 bp)
Type: Toxin
Protein ID: WP_004146663.1
Type: Toxin
Protein ID: WP_004146663.1
Location: 1679963..1680649 (687 bp)
Type: Others
Protein ID: WP_004151733.1
Type: Others
Protein ID: WP_004151733.1
Location: 1681111..1683258 (2148 bp)
Type: Others
Protein ID: WP_012737173.1
Type: Others
Protein ID: WP_012737173.1
Location: 1686151..1687158 (1008 bp)
Type: Others
Protein ID: WP_009484222.1
Type: Others
Protein ID: WP_009484222.1
Location: 1687233..1688174 (942 bp)
Type: Others
Protein ID: WP_002885156.1
Type: Others
Protein ID: WP_002885156.1
Location: 1688205..1689203 (999 bp)
Type: Others
Protein ID: WP_002885172.1
Type: Others
Protein ID: WP_002885172.1
Location: 1689200..1690720 (1521 bp)
Type: Others
Protein ID: WP_004210021.1
Type: Others
Protein ID: WP_004210021.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I6K46_RS08100 | 1679963..1680649 | - | 687 | WP_004151733.1 | sel1 repeat family protein | - |
I6K46_RS08105 | 1681111..1683258 | - | 2148 | WP_012737173.1 | formate dehydrogenase H subunit alpha, selenocysteine-containing | - |
I6K46_RS08110 | 1683531..1684259 | + | 729 | WP_002885152.1 | response regulator transcription factor | - |
I6K46_RS08115 | 1684345..1685103 | + | 759 | WP_004177809.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
I6K46_RS08120 | 1685109..1686026 | + | 918 | WP_004146663.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
I6K46_RS08125 | 1686151..1687158 | - | 1008 | WP_009484222.1 | carbohydrate kinase family protein | - |
I6K46_RS08130 | 1687233..1688174 | - | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
I6K46_RS08135 | 1688205..1689203 | - | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
I6K46_RS08140 | 1689200..1690720 | - | 1521 | WP_004210021.1 | sugar ABC transporter ATP-binding protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34659.10 Da Isoelectric Point: 5.4707
>T193052 WP_004146663.1 NZ_CP070092:1685109-1686026 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
>T193052 NZ_CP092656:1330946-1331356 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
Antitoxin
Download Length: 253 a.a. Molecular weight: 28548.92 Da Isoelectric Point: 10.0870
>AT193052 WP_004177809.1 NZ_CP070092:1684345-1685103 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
>AT193052 NZ_CP092656:1330699-1330965 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA