Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 478965..479622 Replicon chromosome
Accession NZ_CP070092
Organism Klebsiella pneumoniae strain FDAARGOS_1316

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag I6K46_RS02300 Protein ID WP_002916310.1
Coordinates 478965..479375 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag I6K46_RS02305 Protein ID WP_002916312.1
Coordinates 479356..479622 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K46_RS02280 474965..476698 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
I6K46_RS02285 476704..477417 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6K46_RS02290 477440..478336 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
I6K46_RS02295 478437..478958 + 522 WP_002916308.1 flavodoxin FldB -
I6K46_RS02300 478965..479375 - 411 WP_002916310.1 protein YgfX Toxin
I6K46_RS02305 479356..479622 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
I6K46_RS02310 479868..480851 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
I6K46_RS02315 481002..481661 - 660 WP_002916317.1 hemolysin III family protein -
I6K46_RS02320 481825..482136 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
I6K46_RS02325 482186..482914 + 729 WP_009485882.1 MurR/RpiR family transcriptional regulator -
I6K46_RS02330 483033..484466 + 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T193049 WP_002916310.1 NZ_CP070092:c479375-478965 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T193049 NZ_CP092656:782014-782382 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT193049 WP_002916312.1 NZ_CP070092:c479622-479356 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT193049 NZ_CP092656:781796-782017 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References