Detailed information of TA system TA193043

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3274507..3276188
• Replicon: chromosome
• Accession: NZ_CP070088
• Organism: Klebsiella pneumoniae strain FDAARGOS_1306

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: I6K36_RS15860
• Protein ID: WP_048999664.1
• Coordinates: 3274507..3275424 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: I6K36_RS15865
• Protein ID: WP_204746226.1
• Coordinates: 3275430..3276188 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K36_RS15840	3269813..3271333	+	1521	WP_004210021.1	sugar ABC transporter ATP-binding protein	-
I6K36_RS15845	3271330..3272328	+	999	WP_004186549.1	ribose ABC transporter permease	-
I6K36_RS15850	3272359..3273300	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
I6K36_RS15855	3273375..3274382	+	1008	WP_004210019.1	carbohydrate kinase family protein	-
I6K36_RS15860	3274507..3275424	-	918	WP_048999664.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
I6K36_RS15865	3275430..3276188	-	759	WP_204746226.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
I6K36_RS15870	3276274..3277002	-	729	WP_023288135.1	response regulator transcription factor	-
I6K36_RS15875	3277275..3279422	+	2148	WP_077598991.1	formate dehydrogenase subunit alpha	-
I6K36_RS15880	3279419..3279562	-	144	WP_022631365.1	hypothetical protein	-
I6K36_RS15885	3280116..3280802	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34743.22 Da
• Isoelectric Point: 5.4707

>T193043 WP_048999664.1 NZ_CP070088:c3275424-3274507 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALRGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIVANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T193043 NZ_CP092652:3964013-3964399 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATCGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAGATATGACTGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28640.98 Da
• Isoelectric Point: 10.0001

>AT193043 WP_204746226.1 NZ_CP070088:c3276188-3275430 [Klebsiella pneumoniae]
METKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDAFACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT193043 NZ_CP092652:3964392-3964712 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAGGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTGCATTTAATAGATAAAAAAATATTATTCATCTA
G