Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3114118..3114634 Replicon chromosome
Accession NZ_CP070088
Organism Klebsiella pneumoniae strain FDAARGOS_1306

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag I6K36_RS15045 Protein ID WP_009309309.1
Coordinates 3114118..3114402 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag I6K36_RS15050 Protein ID WP_002886901.1
Coordinates 3114392..3114634 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K36_RS15020 3109514..3109822 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
I6K36_RS15025 3109907..3110080 + 174 WP_004222159.1 hypothetical protein -
I6K36_RS15030 3110083..3110826 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
I6K36_RS15035 3111183..3113321 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
I6K36_RS15040 3113650..3114114 + 465 WP_049000498.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I6K36_RS15045 3114118..3114402 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6K36_RS15050 3114392..3114634 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6K36_RS15055 3114712..3116622 - 1911 WP_049000497.1 BglG family transcription antiterminator -
I6K36_RS15060 3116645..3117799 - 1155 WP_049000495.1 lactonase family protein -
I6K36_RS15065 3117866..3118606 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T193042 WP_009309309.1 NZ_CP070088:c3114402-3114118 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T193042 NZ_CP092652:c3590522-3589584 [Proteus mirabilis]
ATGGATAAAGATAGCCCATATTACAAACAGGTTTCTTTGCTCATAAGAATGCTGCCTGTGGTAGCAACAGAGACGGTTTT
TGCACTTAAAGGTGGCACCGCCATTAATTTATTTGTGAGAGATTTTCCTCGGTTATCTGTAGATATTGATCTTGCTTATC
TTCCACTTGAACCAAGAGATGAGGCTTTGATTAATGTCAGGGCTGCATTGCAGCGCATTACAGACAGAATCAATACTCAA
CCAGATATCAGAGCGGCATTTCAGGATAATAAAGCTGATGAACTGAGAATAATTGTATCAAGTCCGGTTGCGACGATCAA
AATTGAAGTGTCGCCCGTCGCCAGAGGTACATTGCATAGTGCAGAAATAATGGCAGTTCAAGAGTCTGTTGAATACGAGT
TTGGTTATGCTGAGATTCAGGTAGTCAGTCTTCCCGATCTGTATGGTGGGAAATTGTGTGCTGCAATGGATCGCCAACAT
CCTCGCGACTTATTTGATGTGCGTATGTTACTTGGCAGTGAAGGGGTTTCGAGAGAGATTTTAGTGGGTTTTTTAACCTA
TACATTAAGTCATCCTCGGCCTATTAATGAAGTCATGTCGCCAAACTGGCAGCCGCTGAATGAGAAATTTCAGGCAGAAT
TTGATGGAATGACTTTTGAAAAAGTTGAATGCGAAGACTTAGCTTCTGTTAGGCCTATGATGTTAACTTCGCTGCAAAAA
CATTTCACAGAAAGGGATTATGCTTTCCTTATGTCATTCAAAAGAGGGCAACCTGACTGGGCATTGTTTGACTATCCTAA
TGCAGCAGACTTGCCAGCGATTCGTTGGAAGTTGCAGAACATAAACAAATTGGCAAAGAATCAAGCAAAACATCAAGAGC
AATTAGATAAATTGAAGCAAGTGCTTGATGATTGGCTTGTTAACGCAAACGCCGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT193042 WP_002886901.1 NZ_CP070088:c3114634-3114392 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT193042 NZ_CP092652:c3591306-3590515 [Proteus mirabilis]
ATGTCATCTAAAATAAACTGGCTTGTTGCTCATACTTCTCCTGGTGCGCTAGTACTTCAGCAATGGCTGACTGAAAACGG
CGTGAGCTACTCGTTGGCTCAAAAGTACGCGCAGAACGGTTGGCTGAAGAAGCTTAGTTCTGGTGTGTACTATCGTCCAA
ATGCGCAGGGCGATATAAAGCCAACTTGGGTTGATGCCATTCAAGCATTGGATGTGCAATTGGGCGTTCCAGTTCATTTG
GCTGGATTGAGCAGCTTAACTCACCAAGGACTGAGTCACTATTTGCAGCTGAACAAAGAGCAAGTTTGGATTTGCGTTAA
AAACAAGTCGTCCTTACCGAAATGGTTTCGTGAATTCCCTTATCAGAATTGGTTTTACTGCGGAAACCATAAGCTTGAAG
TGAATCCCGAGAAAGATTTGAAAAGGATCACGGTTAAAGAGAAAGAGCTCACTGTCAGCTGTGCAGAACTTGCTGCCTAT
GAAGTGGTAGATGCGATTGGAAAGCTGATTTCATTTGAGCATGTCGCAGAATTATTTCAGGGTTTAGTCAATCTTAGCCC
TAGAAAAGTACAAGATATTCTTGAACGAAGCAGCTCTGTTCAGGCAAACCGAATATTTCTATTTCTGGGTCGATACTACG
ATCACCAGTGGGTCAATCGCATAGATGAAACAAGAATTAAATTGGGGGCAGGAAAGCGGCAGGTTGTCGAAAAAGGACGT
TTTGATGAGCGATATCAAATCACAGTGCCAGAGATATTAAGCGTCAAAAAAGGTGAACAACATAATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References