Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2392110..2392729 Replicon chromosome
Accession NZ_CP070088
Organism Klebsiella pneumoniae strain FDAARGOS_1306

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag I6K36_RS11625 Protein ID WP_002892050.1
Coordinates 2392511..2392729 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag I6K36_RS11620 Protein ID WP_002892066.1
Coordinates 2392110..2392484 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K36_RS11610 2387262..2388455 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
I6K36_RS11615 2388478..2391624 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
I6K36_RS11620 2392110..2392484 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
I6K36_RS11625 2392511..2392729 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
I6K36_RS11630 2392892..2393458 + 567 WP_135664579.1 maltose O-acetyltransferase -
I6K36_RS11635 2393430..2393570 - 141 WP_004147370.1 hypothetical protein -
I6K36_RS11640 2393591..2394061 + 471 WP_002892026.1 YlaC family protein -
I6K36_RS11645 2394036..2395487 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
I6K36_RS11650 2395588..2396286 + 699 WP_135664576.1 GNAT family N-acetyltransferase -
I6K36_RS11655 2396283..2396423 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
I6K36_RS11660 2396423..2396686 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T193039 WP_002892050.1 NZ_CP070088:2392511-2392729 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T193039 NZ_CP092652:c1720012-1719827 [Proteus mirabilis]
TTGAAAAGTTCGGAACTGATTAAGTTGTTAGAAAAAAACGGATGGATACTTGATAGAATAAAAGGAAGTCATCATCAATT
TACTCACCCTGATTTTTCTTTTGTTGTAACAGTACCGCATCCAAGAAAAGATTTAAAAAAAGGAACATTAAATCAAATTA
TTAAAAGTGCCAAACTGAAAAATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT193039 WP_002892066.1 NZ_CP070088:2392110-2392484 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT193039 NZ_CP092652:c1719780-1719367 [Proteus mirabilis]
ATGTTATATCCAGCCTTTATTGAAATTGATGAAGATGGTAGCGCAAGTGGCTGGTTCCCTGATATTGATGGTTGCATCTT
TGCGGGGGACAGTATTGAAGAAGCTCACGCAGATGCGAGGAGCGCTATTGATGCCCATTTTGAATTGTTAAGCGAGAAGG
GTTTAGATATCCCCTCTCCAAAATCTCAACAAGAGCATTTAATTAATTCTAGTGGTGATTACAATAATGGAATATGGCTT
TTAGTTGATGTTGATATGGATAAATACGACGGACGAGCAGAGCGTATTAATATCACATTGCCACATCGATTATTGAGTCG
CATCGATACTATCGTAAAAACAAATCCTGAATATGGGAGTCGTAGCGGATTTATTGCCACAGCAACCCGTAAAGAACTCC
AAAAGAATATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References