Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 4581948..4582474 | Replicon | chromosome |
| Accession | NZ_CP070077 | ||
| Organism | Escherichia coli strain FDAARGOS_1371 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | I6L01_RS21665 | Protein ID | WP_000323025.1 |
| Coordinates | 4582187..4582474 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | I6L01_RS21660 | Protein ID | WP_204628246.1 |
| Coordinates | 4581948..4582187 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6L01_RS21635 (4577210) | 4577210..4577824 | + | 615 | WP_001265627.1 | hypothetical protein | - |
| I6L01_RS21640 (4577827) | 4577827..4578849 | + | 1023 | WP_000915483.1 | DUF4868 domain-containing protein | - |
| I6L01_RS21645 (4579354) | 4579354..4580376 | + | 1023 | Protein_4247 | ISNCY family transposase | - |
| I6L01_RS24765 (4580497) | 4580497..4580646 | + | 150 | WP_011443592.1 | protein YdfW | - |
| I6L01_RS21650 (4581083) | 4581083..4581415 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| I6L01_RS21655 (4581618) | 4581618..4581923 | - | 306 | WP_001326990.1 | protein YdfV | - |
| I6L01_RS21660 (4581948) | 4581948..4582187 | + | 240 | WP_204628246.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| I6L01_RS21665 (4582187) | 4582187..4582474 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| I6L01_RS21670 (4582546) | 4582546..4582701 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| I6L01_RS21675 (4582918) | 4582918..4583169 | + | 252 | WP_000980994.1 | protein Rem | - |
| I6L01_RS21680 (4583236) | 4583236..4583514 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| I6L01_RS21685 (4583516) | 4583516..4584565 | + | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| I6L01_RS21690 (4584579) | 4584579..4585331 | + | 753 | WP_001047135.1 | antitermination protein | - |
| I6L01_RS21695 (4585609) | 4585609..4585698 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| I6L01_RS21700 (4585753) | 4585753..4585965 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| I6L01_RS21705 (4586266) | 4586266..4586481 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| I6L01_RS21710 (4586932) | 4586932..4587390 | + | 459 | WP_000526135.1 | IS200/IS605-like element IS200C family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 4567430..4621443 | 54013 | |
| - | flank | IS/Tn | - | - | 4586932..4587390 | 458 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T193002 WP_000323025.1 NZ_CP070077:4582187-4582474 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T193002 NZ_CP092645:c39109-38729 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCTGGCATGTC
AGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTCCAGGCCAGAGTTGTGTACGAAGAGATTACCGACCTTTTCGAAG
TCTCCGCAACCTACCTGGTGGCTACTGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCCGCGGAGTAG
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCTGGCATGTC
AGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTCCAGGCCAGAGTTGTGTACGAAGAGATTACCGACCTTTTCGAAG
TCTCCGCAACCTACCTGGTGGCTACTGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCCGCGGAGTAG
Antitoxin
Download Length: 80 a.a. Molecular weight: 9098.50 Da Isoelectric Point: 4.5230
>AT193002 WP_204628246.1 NZ_CP070077:4581948-4582187 [Escherichia coli]
MGNINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGNINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT193002 NZ_CP092645:c39330-39109 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|