Detailed information of TA system TA192989

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2981022..2981856
• Replicon: chromosome
• Accession: NZ_CP070077
• Organism: Escherichia coli strain FDAARGOS_1371

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A8E0IX31
• Locus tag: I6L01_RS13990
• Protein ID: WP_000854689.1
• Coordinates: 2981022..2981399 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A8E0IVP8
• Locus tag: I6L01_RS13995
• Protein ID: WP_001285599.1
• Coordinates: 2981476..2981856 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L01_RS13960 (2977416)	2977416..2977586	-	171	Protein_2735	IS110 family transposase	-
I6L01_RS13965 (2978003)	2978003..2978936	-	934	Protein_2736	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
I6L01_RS13970 (2978929)	2978929..2979324	-	396	WP_000208381.1	DUF6088 family protein	-
I6L01_RS13975 (2979393)	2979393..2980238	-	846	WP_001446750.1	DUF4942 domain-containing protein	-
I6L01_RS13980 (2980323)	2980323..2980520	-	198	WP_000839250.1	DUF957 domain-containing protein	-
I6L01_RS13985 (2980537)	2980537..2981025	-	489	WP_000761698.1	DUF5983 family protein	-
I6L01_RS13990 (2981022)	2981022..2981399	-	378	WP_000854689.1	TA system toxin CbtA family protein	Toxin
I6L01_RS13995 (2981476)	2981476..2981856	-	381	WP_001285599.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
I6L01_RS14000 (2981906)	2981906..2982550	-	645	WP_000086757.1	hypothetical protein	-
I6L01_RS14005 (2982569)	2982569..2982790	-	222	WP_000692315.1	DUF987 domain-containing protein	-
I6L01_RS14010 (2982853)	2982853..2983329	-	477	WP_001186761.1	RadC family protein	-
I6L01_RS14015 (2983345)	2983345..2983818	-	474	WP_001538139.1	antirestriction protein	-
I6L01_RS14020 (2984082)	2984082..2984903	-	822	WP_001234555.1	DUF932 domain-containing protein	-
I6L01_RS24720 (2985082)	2985082..2985171	-	90	WP_225385657.1	DUF905 family protein	-
I6L01_RS14030 (2985314)	2985314..2985769	-	456	WP_001309747.1	IrmA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2977416..2977571	155

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14042.07 Da
• Isoelectric Point: 9.1510

>T192989 WP_000854689.1 NZ_CP070077:c2981399-2981022 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Nucleotide

• Length: 378 bp

>T192989 NZ_CP092639:1968451-1968554 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 13984.78 Da
• Isoelectric Point: 5.0823

>AT192989 WP_001285599.1 NZ_CP070077:c2981856-2981476 [Escherichia coli]
MSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLLQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Nucleotide

• Length: 381 bp

>AT192989 NZ_CP092639:c1968592-1968321 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT