192984

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 1492701..1493296 Replicon chromosome
Accession NZ_CP070077
Organism Escherichia coli strain FDAARGOS_1371

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag I6L01_RS07010 Protein ID WP_000239581.1
Coordinates 1492701..1493051 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag I6L01_RS07015 Protein ID WP_001223213.1
Coordinates 1493045..1493296 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L01_RS06990 (1488155) 1488155..1489177 - 1023 WP_126709144.1 ABC transporter permease -
I6L01_RS06995 (1489191) 1489191..1490693 - 1503 WP_001522399.1 sugar ABC transporter ATP-binding protein -
I6L01_RS07000 (1490826) 1490826..1491782 - 957 WP_001522398.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
I6L01_RS07005 (1492092) 1492092..1492622 + 531 WP_000055075.1 inorganic diphosphatase -
I6L01_RS07010 (1492701) 1492701..1493051 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
I6L01_RS07015 (1493045) 1493045..1493296 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
I6L01_RS07020 (1493508) 1493508..1493849 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
I6L01_RS07025 (1493852) 1493852..1497631 - 3780 WP_001522396.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T192984 WP_000239581.1 NZ_CP070077:c1493051-1492701 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T192984 NZ_CP092639:842565-842972 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT192984 WP_001223213.1 NZ_CP070077:c1493296-1493045 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT192984 NZ_CP092639:842318-842584 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References