Detailed information of TA system TA192982

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 1379598..1380412
• Replicon: chromosome
• Accession: NZ_CP070077
• Organism: Escherichia coli strain FDAARGOS_1371

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: I6L01_RS06450
• Protein ID: WP_001054376.1
• Coordinates: 1379598..1379855 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: I6L01_RS06455
• Protein ID: WP_001309181.1
• Coordinates: 1379867..1380412 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L01_RS06430 (1374886)	1374886..1375992	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
I6L01_RS06435 (1376057)	1376057..1377037	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
I6L01_RS24610 (1377147)	1377147..1377352	+	206	Protein_1258	HNH endonuclease	-
I6L01_RS06440 (1377620)	1377620..1378860	-	1241	Protein_1259	helicase YjhR	-
I6L01_RS24615 (1378976)	1378976..1379107	+	132	WP_001309182.1	hypothetical protein	-
I6L01_RS06450 (1379598)	1379598..1379855	+	258	WP_001054376.1	YjhX family toxin	Toxin
I6L01_RS06455 (1379867)	1379867..1380412	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
I6L01_RS06460 (1380468)	1380468..1381214	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
I6L01_RS06465 (1381383)	1381383..1381601	+	219	Protein_1264	hypothetical protein	-
I6L01_RS06470 (1381639)	1381639..1381755	+	117	Protein_1265	VOC family protein	-
I6L01_RS06475 (1382000)	1382000..1383121	+	1122	WP_000010829.1	M42 family metallopeptidase	-
I6L01_RS06480 (1383118)	1383118..1383396	+	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
I6L01_RS06485 (1383408)	1383408..1384721	+	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimI / fimA / fimE / fimB	1369385..1388636	19251

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T192982 WP_001054376.1 NZ_CP070077:1379598-1379855 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T192982 NZ_CP092639:633102-633416 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTAGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT192982 WP_001309181.1 NZ_CP070077:1379867-1380412 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT192982 NZ_CP092639:633413-633829 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCGGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGCTCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8