192979

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 766689..767307 Replicon chromosome
Accession NZ_CP070077
Organism Escherichia coli strain FDAARGOS_1371

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag I6L01_RS03595 Protein ID WP_001291435.1
Coordinates 767089..767307 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag I6L01_RS03590 Protein ID WP_000344800.1
Coordinates 766689..767063 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L01_RS03580 (761778) 761778..762971 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
I6L01_RS03585 (762994) 762994..766143 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
I6L01_RS03590 (766689) 766689..767063 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
I6L01_RS03595 (767089) 767089..767307 + 219 WP_001291435.1 HHA domain-containing protein Toxin
I6L01_RS03600 (767479) 767479..768030 + 552 WP_001522034.1 maltose O-acetyltransferase -
I6L01_RS03605 (768146) 768146..768616 + 471 WP_001490888.1 YlaC family protein -
I6L01_RS03610 (768780) 768780..770330 + 1551 WP_033550876.1 cyclic-guanylate-specific phosphodiesterase PdeB -
I6L01_RS03615 (770372) 770372..770725 - 354 WP_000878140.1 DUF1428 domain-containing protein -
I6L01_RS03625 (771104) 771104..771415 + 312 WP_000409911.1 MGMT family protein -
I6L01_RS03630 (771446) 771446..772018 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T192979 WP_001291435.1 NZ_CP070077:767089-767307 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T192979 NZ_CP092639:181826-181933 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT192979 WP_000344800.1 NZ_CP070077:766689-767063 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT192979 NZ_CP092639:c181769-181712 [Escherichia coli]
TCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References