192978

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 343335..344040 Replicon chromosome
Accession NZ_CP070077
Organism Escherichia coli strain FDAARGOS_1371

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag I6L01_RS01750 Protein ID WP_000539521.1
Coordinates 343335..343721 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag I6L01_RS01755 Protein ID WP_001280945.1
Coordinates 343711..344040 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L01_RS01730 (339339) 339339..339965 + 627 WP_020233670.1 glutathione S-transferase GstB -
I6L01_RS01735 (339962) 339962..341077 - 1116 WP_000555050.1 aldose sugar dehydrogenase YliI -
I6L01_RS01740 (341188) 341188..341571 - 384 WP_000497137.1 biofilm formation regulator BssR -
I6L01_RS01745 (341784) 341784..343109 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
I6L01_RS01750 (343335) 343335..343721 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L01_RS01755 (343711) 343711..344040 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
I6L01_RS01760 (344110) 344110..345438 - 1329 WP_000086873.1 GGDEF domain-containing protein -
I6L01_RS01765 (345446) 345446..347794 - 2349 WP_021523051.1 EAL domain-containing protein -
I6L01_RS01770 (347972) 347972..348883 - 912 WP_001236019.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T192978 WP_000539521.1 NZ_CP070077:343335-343721 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T192978 NZ_CP092639:181343-181450 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT192978 WP_001280945.1 NZ_CP070077:343711-344040 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT192978 NZ_CP092639:c181286-181229 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References