Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/RelE-RHH |
| Location | 16403..16950 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP070072 | ||
| Organism | Escherichia coli strain FDAARGOS_1287 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G7QEJ9 |
| Locus tag | I6K17_RS25725 | Protein ID | WP_001384452.1 |
| Coordinates | 16672..16950 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | - |
| Locus tag | I6K17_RS25720 | Protein ID | WP_076838292.1 |
| Coordinates | 16403..16672 (+) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6K17_RS25680 (11605) | 11605..12165 | + | 561 | WP_025670714.1 | fertility inhibition protein FinO | - |
| I6K17_RS25685 (12301) | 12301..12513 | + | 213 | WP_001299730.1 | ANR family transcriptional regulator | - |
| I6K17_RS25690 (12759) | 12759..12833 | + | 75 | Protein_11 | endonuclease | - |
| - (13089) | 13089..13150 | - | 62 | NuclAT_1 | - | - |
| - (13089) | 13089..13150 | - | 62 | NuclAT_1 | - | - |
| - (13089) | 13089..13150 | - | 62 | NuclAT_1 | - | - |
| - (13089) | 13089..13150 | - | 62 | NuclAT_1 | - | - |
| I6K17_RS25695 (13194) | 13194..13343 | + | 150 | WP_001312851.1 | Hok/Gef family protein | - |
| I6K17_RS25700 (13627) | 13627..13884 | + | 258 | WP_000083845.1 | replication regulatory protein RepA | - |
| I6K17_RS27915 (13901) | 13901..14152 | - | 252 | WP_223195197.1 | replication protein RepA | - |
| I6K17_RS27920 (14143) | 14143..14190 | + | 48 | WP_229471593.1 | hypothetical protein | - |
| I6K17_RS25710 (14183) | 14183..14665 | + | 483 | WP_001273588.1 | hypothetical protein | - |
| I6K17_RS25715 (14658) | 14658..15491 | + | 834 | WP_204609276.1 | incFII family plasmid replication initiator RepA | - |
| I6K17_RS25720 (16403) | 16403..16672 | + | 270 | WP_076838292.1 | type II toxin-antitoxin system antitoxin YacA | Antitoxin |
| I6K17_RS25725 (16672) | 16672..16950 | + | 279 | WP_001384452.1 | type II toxin-antitoxin system toxin YacB | Toxin |
| I6K17_RS25730 (16986) | 16986..17826 | + | 841 | Protein_20 | 3'-5' exonuclease | - |
| I6K17_RS25735 (17967) | 17967..18425 | + | 459 | WP_001236004.1 | hypothetical protein | - |
| I6K17_RS25740 (18721) | 18721..19650 | - | 930 | WP_025670909.1 | hypothetical protein | - |
| I6K17_RS25745 (20052) | 20052..20297 | + | 246 | Protein_23 | transposase | - |
| I6K17_RS25750 (20310) | 20310..21461 | - | 1152 | WP_001254932.1 | IS30-like element IS30 family transposase | - |
| I6K17_RS25755 (21529) | 21529..21786 | - | 258 | Protein_25 | IS3 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | sitABCD | vat / iroN / iroE / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA | 1..136908 | 136908 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10762.38 Da Isoelectric Point: 8.4615
>T192967 WP_001384452.1 NZ_CP070072:16672-16950 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP
Download Length: 279 bp
>T192967 NZ_CP092635:30746-31060 [Enterobacter cloacae]
ATGCATTTAATCTCGATGAAGGCAATTTTGGATGCGGTTATCCAGTTTCCGCAGCACAGGGAAGAACTCCTCGTTTTGGG
ACGCACTCTTGAAAAGAGTCATTGCCCAACACCTGCTGCGTTAAAAAAACTATTTCCGACGCTGGATAACTTCAAGTATC
TGGATAAGCATTATGTTATTGATATTGCGAACAACAATCTTAGGGTAGTGGCTCTCATATTCTTTGAAAGCCAAAAGTTT
TATGTGCGCCATGTTTTTACTCATAAGGAATATGACCGTTTTACGGAAAAACATCGCACTAAGGGGAAGAAATGA
ATGCATTTAATCTCGATGAAGGCAATTTTGGATGCGGTTATCCAGTTTCCGCAGCACAGGGAAGAACTCCTCGTTTTGGG
ACGCACTCTTGAAAAGAGTCATTGCCCAACACCTGCTGCGTTAAAAAAACTATTTCCGACGCTGGATAACTTCAAGTATC
TGGATAAGCATTATGTTATTGATATTGCGAACAACAATCTTAGGGTAGTGGCTCTCATATTCTTTGAAAGCCAAAAGTTT
TATGTGCGCCATGTTTTTACTCATAAGGAATATGACCGTTTTACGGAAAAACATCGCACTAAGGGGAAGAAATGA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10174.52 Da Isoelectric Point: 8.8928
>AT192967 WP_076838292.1 NZ_CP070072:16403-16672 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLEHGNVLPHDMVESSAAAWRD
EMSRKVAGK
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLEHGNVLPHDMVESSAAAWRD
EMSRKVAGK
Download Length: 270 bp
>AT192967 NZ_CP092635:31060-31476 [Enterobacter cloacae]
ATGATCGTCGCTGATGCAATGAAAGCTACGCATGCCCTTGTTGAGGCCGTTCCTCTATTGGGAGAGCAGCCGAGCGAGAA
AGATTATAACGATGCACTGGAGTTGGTTGAGTATCTGCTTATTAACGAACCTAATAGCCCATTGCTGGATATCGTGTGCG
CCAGAATCAGCCGTTACGAAGCCAATCGGCCAAAGATCGTCGCGTTACGCAAGGAGATGGAACTCGTGCCTGTCGGTATC
GCGGTTTTAAGAACCTTGATGGATCAGTATAAACTGACAACATCTGATTTTCAGGATGAAATTGGTAGTAAATCAATGGT
TTCAAGGGTTCTGAATGGTCAGCGACAGCTTACTCTGAACCATATTAAAAAGCTGGCGTCCAGATTTGGTGTTTCACCAG
CACTATTTATTGAATAA
ATGATCGTCGCTGATGCAATGAAAGCTACGCATGCCCTTGTTGAGGCCGTTCCTCTATTGGGAGAGCAGCCGAGCGAGAA
AGATTATAACGATGCACTGGAGTTGGTTGAGTATCTGCTTATTAACGAACCTAATAGCCCATTGCTGGATATCGTGTGCG
CCAGAATCAGCCGTTACGAAGCCAATCGGCCAAAGATCGTCGCGTTACGCAAGGAGATGGAACTCGTGCCTGTCGGTATC
GCGGTTTTAAGAACCTTGATGGATCAGTATAAACTGACAACATCTGATTTTCAGGATGAAATTGGTAGTAAATCAATGGT
TTCAAGGGTTCTGAATGGTCAGCGACAGCTTACTCTGAACCATATTAAAAAGCTGGCGTCCAGATTTGGTGTTTCACCAG
CACTATTTATTGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|