Detailed information of TA system TA192951

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3108226..3109024
• Replicon: chromosome
• Accession: NZ_CP070071
• Organism: Escherichia coli strain FDAARGOS_1287

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: I6K17_RS16075
• Protein ID: WP_021527178.1
• Coordinates: 3108226..3108603 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A2G4AEZ5
• Locus tag: I6K17_RS16080
• Protein ID: WP_001285608.1
• Coordinates: 3108650..3109024 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K17_RS16055 (3105960)	3105960..3106103	-	144	Protein_3065	hypothetical protein	-
I6K17_RS16065 (3107524)	3107524..3107721	-	198	WP_001327226.1	DUF957 domain-containing protein	-
I6K17_RS16070 (3107741)	3107741..3108229	-	489	WP_000777664.1	DUF5983 family protein	-
I6K17_RS16075 (3108226)	3108226..3108603	-	378	WP_021527178.1	TA system toxin CbtA family protein	Toxin
I6K17_RS16080 (3108650)	3108650..3109024	-	375	WP_001285608.1	type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA	Antitoxin
I6K17_RS16085 (3109104)	3109104..3109325	-	222	WP_000692350.1	DUF987 domain-containing protein	-
I6K17_RS16090 (3109412)	3109412..3109888	-	477	WP_001186188.1	RadC family protein	-
I6K17_RS16095 (3109903)	3109903..3110382	-	480	WP_000706980.1	antirestriction protein	-
I6K17_RS16100 (3110482)	3110482..3110622	+	141	WP_000997937.1	hypothetical protein	-
I6K17_RS16105 (3110648)	3110648..3111466	-	819	WP_001175165.1	DUF932 domain-containing protein	-
I6K17_RS16110 (3111556)	3111556..3111789	-	234	WP_001278293.1	DUF905 family protein	-
I6K17_RS16115 (3111795)	3111795..3112472	-	678	WP_021527176.1	hypothetical protein	-
I6K17_RS16120 (3112620)	3112620..3113300	-	681	WP_001282921.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimE / fimB / iroB	3094660..3138906	44246

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14027.93 Da
• Isoelectric Point: 7.9086

>T192951 WP_021527178.1 NZ_CP070071:c3108603-3108226 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITLGKHSEAKQ

Nucleotide

• Length: 378 bp

>T192951 NZ_CP092632:788651-789061 [Klebsiella variicola subsp. variicola]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGTTGGTTCCCTGGCCGCTAAGCTACACCCCGATCTGGCTGCTGCTGTTGTCGCTGGTAGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGAGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTCATCAATAGCGGTATGCTGCTGCGTTTACGCCATGTCGATACCCGGCGCGG
GCAGCATCTGTGGCTGGCGGCGGATAGCATGGATGCCGGAGAATGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13610.37 Da
• Isoelectric Point: 5.5051

>AT192951 WP_001285608.1 NZ_CP070071:c3109024-3108650 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPAITS

Nucleotide

• Length: 375 bp

>AT192951 NZ_CP092632:788404-788670 [Klebsiella variicola subsp. variicola]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAACGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A2G4AEZ5