Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2719666..2720464 Replicon chromosome
Accession NZ_CP070071
Organism Escherichia coli strain FDAARGOS_1287

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VRA6
Locus tag I6K17_RS14165 Protein ID WP_000854730.1
Coordinates 2720087..2720464 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P0SQV8
Locus tag I6K17_RS14160 Protein ID WP_001285481.1
Coordinates 2719666..2720040 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K17_RS14120 (2715641) 2715641..2716093 + 453 WP_000682723.1 hypothetical protein -
I6K17_RS14125 (2716211) 2716211..2716444 + 234 WP_001213776.1 DUF905 family protein -
I6K17_RS14130 (2716544) 2716544..2717365 + 822 WP_001234359.1 DUF932 domain-containing protein -
I6K17_RS14135 (2717365) 2717365..2717610 + 246 WP_001164966.1 hypothetical protein -
I6K17_RS14140 (2717704) 2717704..2718177 + 474 WP_001313575.1 antirestriction protein -
I6K17_RS14145 (2718193) 2718193..2718669 + 477 WP_001313574.1 RadC family protein -
I6K17_RS14150 (2718732) 2718732..2718953 + 222 WP_000692315.1 DUF987 domain-containing protein -
I6K17_RS14155 (2718972) 2718972..2719616 + 645 WP_000086759.1 hypothetical protein -
I6K17_RS14160 (2719666) 2719666..2720040 + 375 WP_001285481.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6K17_RS14165 (2720087) 2720087..2720464 + 378 WP_000854730.1 TA system toxin CbtA family protein Toxin
I6K17_RS14170 (2720461) 2720461..2720953 + 493 Protein_2694 DUF5983 family protein -
I6K17_RS14175 (2721032) 2721032..2722020 - 989 Protein_2695 IS630 family transposase -
I6K17_RS14180 (2722168) 2722168..2723761 - 1594 Protein_2696 IS66 family transposase -
I6K17_RS14185 (2723792) 2723792..2724142 - 351 WP_000624707.1 IS66 family insertion sequence element accessory protein TnpB -
I6K17_RS14190 (2724139) 2724139..2724430 - 292 Protein_2698 transposase -
I6K17_RS27770 (2724472) 2724472..2724666 + 195 WP_001313570.1 DUF957 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14212.21 Da        Isoelectric Point: 7.2923

>T192950 WP_000854730.1 NZ_CP070071:2720087-2720464 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 378 bp

>T192950 NZ_CP092632:329761-330129 [Klebsiella variicola subsp. variicola]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGACGTTGCCGG
TATGCCCGACCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCACCTGCTGGTGATTTCTCGCGGCCATATTTTCAATGATGGAAATAAGCGTACGGCACTGTTT
ATTACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCGGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13817.53 Da        Isoelectric Point: 4.7511

>AT192950 WP_001285481.1 NZ_CP070071:2719666-2720040 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT192950 NZ_CP092632:329543-329764 [Klebsiella variicola subsp. variicola]
ATGAGAACGGTTAACTATAGCGAAGCCCGACAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCCGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATTATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V671

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0SQV8

References