Detailed information of TA system TA192947

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 2044464..2045169
• Replicon: chromosome
• Accession: NZ_CP070071
• Organism: Escherichia coli strain FDAARGOS_1287

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S1F406
• Locus tag: I6K17_RS10795
• Protein ID: WP_000539521.1
• Coordinates: 2044464..2044850 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: I6K17_RS10800
• Protein ID: WP_001280945.1
• Coordinates: 2044840..2045169 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K17_RS10775 (2040468)	2040468..2041094	+	627	WP_001295292.1	glutathione S-transferase GstB	-
I6K17_RS10780 (2041091)	2041091..2042206	-	1116	WP_000555041.1	aldose sugar dehydrogenase YliI	-
I6K17_RS10785 (2042317)	2042317..2042700	-	384	WP_000497137.1	biofilm formation regulator BssR	-
I6K17_RS10790 (2042913)	2042913..2044238	+	1326	WP_000049378.1	30S ribosomal protein S12 methylthiotransferase RimO	-
I6K17_RS10795 (2044464)	2044464..2044850	+	387	WP_000539521.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6K17_RS10800 (2044840)	2044840..2045169	+	330	WP_001280945.1	DNA-binding transcriptional regulator	Antitoxin
I6K17_RS10805 (2045239)	2045239..2046567	-	1329	WP_000086919.1	GGDEF domain-containing protein	-
I6K17_RS10810 (2046575)	2046575..2048923	-	2349	Protein_2026	EAL domain-containing protein	-
I6K17_RS10815 (2049101)	2049101..2050012	-	912	WP_001236044.1	glutathione ABC transporter permease GsiD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14293.45 Da
• Isoelectric Point: 9.9296

>T192947 WP_000539521.1 NZ_CP070071:2044464-2044850 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Nucleotide

• Length: 387 bp

>T192947 NZ_CP092631:c2238091-2237840 [Bacillus subtilis]
ATGAACTTCTCCTTTAGTTCCTACCCATATTATAACATGATCAAGCACATTGCAAACATGAAACGATTCTCATTATGGTT
TACCCATATCACATTCATTGGCTTATTCTTAATGTTTCAACTCATTAAGGATTACTTCAGCAGCGAAGCACAAACACTAA
TCAATATAATATTCATAGTCACATGTATCATTGCCATATTGTTGTGGATCATCTATTTTGTATTCCTTAAACTAAGAAAC
AAGTCACACTAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11982.08 Da
• Isoelectric Point: 10.0101

>AT192947 WP_001280945.1 NZ_CP070071:2044840-2045169 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Nucleotide

• Length: 330 bp

>AT192947 NZ_CP092631:2238069-2238169 [Bacillus subtilis]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT

Structures

Toxin

• AlphaFold DB: A0A829GCT6