Detailed information of TA system TA192944

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1405085..1406667
• Replicon: chromosome
• Accession: NZ_CP070071
• Organism: Escherichia coli strain FDAARGOS_1287

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A0J2BJD7
• Locus tag: I6K17_RS07740
• Protein ID: WP_001125469.1
• Coordinates: 1405351..1406667 (+)
• Length: 439 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: I6K17_RS07735
• Protein ID: WP_001296726.1
• Coordinates: 1405085..1405351 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K17_RS07720 (1400229)	1400229..1401182	+	954	WP_000154356.1	transcriptional regulator LsrR	-
I6K17_RS07725 (1401261)	1401261..1402853	+	1593	WP_000113152.1	autoinducer-2 kinase	-
I6K17_RS07730 (1403003)	1403003..1404892	+	1890	Protein_1409	autotransporter barrel domain-containing lipoprotein	-
I6K17_RS07735 (1405085)	1405085..1405351	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
I6K17_RS07740 (1405351)	1405351..1406667	+	1317	WP_001125469.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
I6K17_RS07745 (1406943)	1406943..1407209	+	267	Protein_1412	AraC family transcriptional regulator	-
I6K17_RS07750 (1407643)	1407643..1408206	+	564	WP_001296758.1	type 1 fimbrial major subunit FimA	-
I6K17_RS07755 (1408568)	1408568..1409278	+	711	WP_001195165.1	fimbria/pilus periplasmic chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (7-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 439 a.a.
• Molecular weight: 49275.91 Da
• Isoelectric Point: 8.8783

>T192944 WP_001125469.1 NZ_CP070071:1405351-1406667 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEQLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPQVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHRRLSREWY

Nucleotide

• Length: 1317 bp

>T192944 NZ_CP092630:c4037886-4036585 [Shewanella xiamenensis]
ATGAGTACAGCTAAAACGCTTACGCTAGAGATGCACCTCGGTGATTTAATGATCGGGGAATTATCCTTTGATGCCACGAC
CGACACCTTTGCGGTGTATTACACCAAAGATTGGCAGCAAAGTGGATTTCCACTATCCCCAACGATTCCTTTAGATGGCA
CAGGAACGAGCAATCAAATATCAATGTTTTTGGTCAACTTATTACCAGAAAACAAAGGATTAGATTATCTTATTGAATCG
CTTGGCGTCTCTAAGGGGAATACCTTTGCCTTGATCCGCGCCATTGGTCTCGATACCGCTGGTGCCATCGCTTTCGTTCC
TAAAGGGGCTTTACTGACTGAAACACAATTGCGGCCAATTAAGGCTGAAGAAGTGATTCAACGCATTGAAGATCCAACAA
TGTGGCCGATGGAAATCTGGGACGGCAAACCTCGACTATCGGTAGCGGGTGTTCAACCTAAATTAAACCTGTTTTATAAC
GGGAAAGAATTTGCCTTTGCCGAAGGTACGCTGTCATCGACCCATATAGTTAAATTCGAAAAATATCATCATTTAGTGAT
CAATGAATTTATAACGATGCGTTTAGCCAAAGTGATTGGAATGAATGTGGCGAATGTCGATATTGTTCATTTTGGCAGTT
ACAAAGCCCTTTGTGTTGAACGCTTTGACAGACGTTATATACCAAGCGAGCAAAGGGTGTTAAGAAGGCATATTGTCGAT
AGCTGCCAAGCACTTGGTTTTAGTGTAAGCAAAAAATATGAACGTAATTTCGGTACGGGGCGCGATGTTAAAGATATTCG
TGAAGGGGTCAGTTTTAACAGGCTATTTAGTCTTGCCGCAAAATGCCGCAATCCCGTGGCAGCTAAGCAGGATATGCTGC
AATGGGCGCTATTCAATTTACTGACCGGCAATGCCGATGCACACGGTAAAAACTACTCATTTTTTATGACGCCAAGCGGA
ATGGAGCCAACGCCTTGGTACGATTTGGTCAGCGTGGCTATGTATGAGGATTTTGAACAACAGCTTGCGATGGCTATTGA
TGACGAATTTGAGCCAAATAGCATTTACGCCTATCAATTAGCCGCGTTTATGGATGGCTTGGGTTTACCAAGAAATTTAT
TAGTCAGTAACTTAACGAGAATAGCGCGGAGAATACCGCAGGCAATAGCGGAGGTGATTTTAATGCTCCCGCCCCTTGAT
GAAGATGAAGCATCATTTGTGGCTCATTACAAAGCGCAGTTACTGGCGAGATGTGAACGTTACCTTAGTTTTGCTGACGA
GGTCAGGGATGTGGAAGTGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT192944 WP_001296726.1 NZ_CP070071:1405085-1405351 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT192944 NZ_CP092630:c4038126-4037890 [Shewanella xiamenensis]
ATGGCATCACCGCTAAATCAACAATCCCTCGGCTTGTTAATTAAAGAACGCAGGAAAAGTGCTGCTCTTACTCAAGACGT
GGCGGCCATGCTGTGCGGCGTAACCAAAAAAACGCTGATCCGAGTTGAAAAGGGTGAGGATGTTTATATCTCAACTGTAT
TCAAAATCCTTGATGGTCTGGGGATTGATATCGTTTCGGCTCAAACCAGCAATACCGAAACTAACGGCTGGTATTAA

Structures

Toxin

• AlphaFold DB: A0A0J2BJD7