Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 292785..293410 Replicon chromosome
Accession NZ_CP070071
Organism Escherichia coli strain FDAARGOS_1287

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag I6K17_RS02180 Protein ID WP_000911329.1
Coordinates 293012..293410 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag I6K17_RS02175 Protein ID WP_000450524.1
Coordinates 292785..293012 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K17_RS02150 (288585) 288585..289055 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
I6K17_RS02155 (289055) 289055..289627 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
I6K17_RS02160 (289773) 289773..290651 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
I6K17_RS02165 (290668) 290668..291702 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
I6K17_RS02170 (291915) 291915..292628 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
I6K17_RS02175 (292785) 292785..293012 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
I6K17_RS02180 (293012) 293012..293410 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
I6K17_RS02185 (293557) 293557..294420 + 864 WP_001267498.1 neutral zinc metallopeptidase -
I6K17_RS02190 (294435) 294435..296450 + 2016 WP_000829310.1 tRNA cytosine(34) acetyltransferase TmcA -
I6K17_RS02195 (296524) 296524..297222 + 699 WP_000679819.1 esterase -
I6K17_RS02200 (297303) 297303..297503 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T192930 WP_000911329.1 NZ_CP070071:293012-293410 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T192930 NZ_CP092627:c4151214-4150930 [Salmonella enterica subsp. enterica serovar Thompson]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT192930 WP_000450524.1 NZ_CP070071:292785-293012 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT192930 NZ_CP092627:c4151446-4151204 [Salmonella enterica subsp. enterica serovar Thompson]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References