Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4294756..4295591 Replicon chromosome
Accession NZ_CP070066
Organism Escherichia coli strain FDAARGOS_1296

Toxin (Protein)


Gene name yeeV Uniprot ID Q1R2L4
Locus tag I6K26_RS20785 Protein ID WP_001094426.1
Coordinates 4294756..4295133 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID Q1R2L5
Locus tag I6K26_RS20790 Protein ID WP_001285575.1
Coordinates 4295223..4295591 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K26_RS20765 (4290259) 4290259..4290438 + 180 Protein_4098 peptidase -
I6K26_RS20770 (4290837) 4290837..4292600 - 1764 WP_251301773.1 hypothetical protein -
I6K26_RS24470 (4293828) 4293828..4293977 - 150 Protein_4100 hypothetical protein -
I6K26_RS20775 (4294062) 4294062..4294259 - 198 WP_000839272.1 DUF957 domain-containing protein -
I6K26_RS20780 (4294271) 4294271..4294759 - 489 WP_000761683.1 DUF5983 family protein -
I6K26_RS20785 (4294756) 4294756..4295133 - 378 WP_001094426.1 TA system toxin CbtA family protein Toxin
I6K26_RS20790 (4295223) 4295223..4295591 - 369 WP_001285575.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6K26_RS20795 (4295671) 4295671..4295892 - 222 WP_000692350.1 DUF987 domain-containing protein -
I6K26_RS20800 (4295979) 4295979..4296455 - 477 WP_001298074.1 RadC family protein -
I6K26_RS20805 (4296470) 4296470..4296955 - 486 WP_000213697.1 antirestriction protein -
I6K26_RS20810 (4297046) 4297046..4297864 - 819 WP_001175160.1 DUF932 domain-containing protein -
I6K26_RS20815 (4297954) 4297954..4298187 - 234 WP_001278290.1 DUF905 family protein -
I6K26_RS20820 (4298193) 4298193..4298774 - 582 WP_001353971.1 hypothetical protein -
I6K26_RS20825 (4299017) 4299017..4299697 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB / papI / papB / papH / papC / papD / papJ / papK / papE / papF / papX 4284175..4334541 50366


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14072.99 Da        Isoelectric Point: 7.3523

>T192919 WP_001094426.1 NZ_CP070066:c4295133-4294756 [Escherichia coli]
MNTLPDTHIREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T192919 NZ_CP092590:144228-144710 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13709.52 Da        Isoelectric Point: 6.6258

>AT192919 WP_001285575.1 NZ_CP070066:c4295591-4295223 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT192919 NZ_CP092590:143974-144240 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATTCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454ABD6

Antitoxin

Source ID Structure
AlphaFold DB A0A454ABF5

References