Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 31295..31817 Replicon plasmid unnamed2
Accession NZ_CP070064
Organism Escherichia coli strain FDAARGOS_1372

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag I6L02_RS22600 Protein ID WP_000220561.1
Coordinates 31295..31576 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag I6L02_RS22605 Protein ID WP_000121743.1
Coordinates 31566..31817 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L02_RS22555 (I6L02_22555) 27297..27842 - 546 WP_033559049.1 DNA distortion polypeptide 1 -
I6L02_RS22560 (I6L02_22560) 28158..28430 - 273 WP_072018860.1 hypothetical protein -
I6L02_RS22565 (I6L02_22565) 28443..28592 - 150 WP_000003880.1 hypothetical protein -
I6L02_RS22570 (I6L02_22570) 28662..28841 - 180 WP_033559051.1 hypothetical protein -
I6L02_RS22575 (I6L02_22575) 28884..29213 - 330 WP_000866654.1 hypothetical protein -
I6L02_RS22580 (I6L02_22580) 29307..29549 - 243 WP_000008708.1 hypothetical protein -
I6L02_RS22585 (I6L02_22585) 29539..29808 - 270 WP_001006718.1 hypothetical protein -
I6L02_RS22590 (I6L02_22590) 29817..30365 - 549 WP_033559052.1 hypothetical protein -
I6L02_RS22595 (I6L02_22595) 30439..30954 - 516 WP_001025387.1 J domain-containing protein -
I6L02_RS22600 (I6L02_22600) 31295..31576 - 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L02_RS22605 (I6L02_22605) 31566..31817 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
I6L02_RS22610 (I6L02_22610) 31909..32076 + 168 WP_157837492.1 hypothetical protein -
I6L02_RS22615 (I6L02_22615) 32637..33629 + 993 WP_274539631.1 replication initiation protein -
I6L02_RS22620 (I6L02_22620) 33638..34081 + 444 WP_032180581.1 hypothetical protein -
I6L02_RS22625 (I6L02_22625) 34259..34612 + 354 WP_032180583.1 DNA distortion polypeptide 3 -
I6L02_RS22630 (I6L02_22630) 34694..35005 - 312 WP_032180585.1 hypothetical protein -
I6L02_RS22635 (I6L02_22635) 35020..35502 - 483 WP_032180587.1 hypothetical protein -
I6L02_RS22640 (I6L02_22640) 35528..35812 - 285 WP_032180591.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..36331 36331


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T192898 WP_000220561.1 NZ_CP070064:c31576-31295 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

>T192898 NZ_CP092581:c2097973-2097764 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT192898 WP_000121743.1 NZ_CP070064:c31817-31566 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT192898 NZ_CP092581:c2098278-2097985 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References