Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1042503..1043025 Replicon chromosome
Accession NZ_CP070063
Organism Escherichia coli strain FDAARGOS_1372

Toxin (Protein)


Gene name relE Uniprot ID V0VCV4
Locus tag I6L02_RS04805 Protein ID WP_001105537.1
Coordinates 1042735..1043025 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag I6L02_RS04800 Protein ID WP_000212715.1
Coordinates 1042503..1042745 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L02_RS04780 (1038214) 1038214..1039587 + 1374 WP_001219792.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -
I6L02_RS04785 (1039745) 1039745..1040296 - 552 WP_000166276.1 ribosome biogenesis factor YjgA -
I6L02_RS04790 (1040390) 1040390..1041742 + 1353 WP_001162187.1 metalloprotease PmbA -
I6L02_RS04795 (1041925) 1041925..1042311 + 387 WP_001232246.1 cytochrome b562 -
I6L02_RS04800 (1042503) 1042503..1042745 + 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6L02_RS04805 (1042735) 1042735..1043025 + 291 WP_001105537.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L02_RS04810 (1043026) 1043026..1043490 - 465 WP_001106233.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I6L02_RS04815 (1043648) 1043648..1045786 - 2139 WP_000187799.1 anaerobic ribonucleoside-triphosphate reductase -
I6L02_RS04820 (1046180) 1046180..1047835 - 1656 WP_001338059.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11383.19 Da        Isoelectric Point: 9.8531

>T192871 WP_001105537.1 NZ_CP070063:1042735-1043025 [Escherichia coli]
MNYELTFDPRALKEWQKLGVTVREQFKKKLEDALKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDADKRLDE

Download         Length: 291 bp

>T192871 NZ_CP092569:532169-532510 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT192871 WP_000212715.1 NZ_CP070063:1042503-1042745 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT192871 NZ_CP092569:531939-532169 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0VCV4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References