Detailed information of TA system TA192866

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 137530..138052
• Replicon: chromosome
• Accession: NZ_CP070062
• Organism: Coprococcus comes strain FDAARGOS_1339

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: I6K69_RS00680
• Protein ID: WP_147574863.1
• Coordinates: 137789..138052 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: C0B4N5
• Locus tag: I6K69_RS00675
• Protein ID: WP_008372201.1
• Coordinates: 137530..137796 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K69_RS00645	132577..133875	-	1299	WP_022219878.1	nucleotidyltransferase	-
I6K69_RS00650	134076..135263	+	1188	WP_008372212.1	acetate kinase	-
I6K69_RS00655	135361..135888	+	528	WP_008372210.1	DUF177 domain-containing protein	-
I6K69_RS00660	135892..136074	+	183	WP_008372209.1	50S ribosomal protein L32	-
I6K69_RS00665	136737..136976	+	240	WP_008372205.1	helix-turn-helix domain-containing protein	-
I6K69_RS00670	137096..137425	+	330	WP_008372203.1	nucleotidyltransferase domain-containing protein	-
I6K69_RS00675	137530..137796	+	267	WP_008372201.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
I6K69_RS00680	137789..138052	+	264	WP_147574863.1	Txe/YoeB family addiction module toxin	Toxin
I6K69_RS00685	138087..138302	-	216	WP_008372198.1	hypothetical protein	-
I6K69_RS00690	138582..138827	+	246	WP_008372194.1	hypothetical protein	-
I6K69_RS00695	139100..140167	+	1068	WP_204575905.1	phosphate acyltransferase PlsX	-
I6K69_RS00700	140189..140419	+	231	WP_008372189.1	acyl carrier protein	-
I6K69_RS00705	140487..141182	+	696	WP_044998976.1	ribonuclease III	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	126004..290136	164132

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10462.76 Da
• Isoelectric Point: 8.7936

>T192866 WP_147574863.1 NZ_CP070062:137789-138052 [Coprococcus comes]
MNKVFTDNGWEDYTYWQTEDKKTLKKINNLIKDIDRNGNEGIGKPEPLTGNLTGFWSRRINDKDRLIYKIDDKNIYILSC
RYHYNDK

Nucleotide

• Length: 264 bp

>T192866 NZ_CP092567:c2144584-2144222 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10288.53 Da
• Isoelectric Point: 4.2086

>AT192866 WP_008372201.1 NZ_CP070062:137530-137796 [Coprococcus comes]
MLAVNYTNLRDNMKSYMDQVTDDYETMIVTRKNNKNVVMMSEEAYNNLMENVYVMGNKANYDWLMESKAQLEKGNFASHT
LSEVVDDE

Nucleotide

• Length: 267 bp

>AT192866 NZ_CP092567:c2144751-2144581 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A173STE0