Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 897394..897903 Replicon chromosome
Accession NZ_CP070057
Organism Staphylococcus epidermidis strain FDAARGOS_1361

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag I6K91_RS04215 Protein ID WP_001829980.1
Coordinates 897394..897603 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag I6K91_RS04220 Protein ID WP_001829893.1
Coordinates 897610..897903 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K91_RS04195 892972..894327 - 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
I6K91_RS04200 894339..895412 - 1074 WP_001832735.1 D-alanine--D-alanine ligase -
I6K91_RS04205 895803..897014 + 1212 WP_001829910.1 rod shape-determining protein RodA -
I6K91_RS04210 897114..897251 - 138 WP_001829949.1 hypothetical protein -
I6K91_RS04215 897394..897603 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
I6K91_RS04220 897610..897903 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
I6K91_RS04225 898077..899561 + 1485 WP_001829964.1 cardiolipin synthase -
I6K91_RS04230 899743..900396 + 654 WP_001829983.1 HD domain-containing protein -
I6K91_RS04235 900502..901374 - 873 WP_001832740.1 membrane protein insertase YidC -
I6K91_RS04240 901463..902101 - 639 WP_002505076.1 thiamine phosphate synthase -
I6K91_RS04245 902107..902895 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T192862 WP_001829980.1 NZ_CP070057:c897603-897394 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T192862 NZ_CP092565:c2499209-2498943 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT192862 WP_001829893.1 NZ_CP070057:c897903-897610 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT192862 NZ_CP092565:c2499466-2499209 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References