Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 886191..886720 Replicon chromosome
Accession NZ_CP070057
Organism Staphylococcus epidermidis strain FDAARGOS_1361

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag I6K91_RS04155 Protein ID WP_001829891.1
Coordinates 886191..886553 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag I6K91_RS04160 Protein ID WP_001829931.1
Coordinates 886550..886720 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K91_RS04135 883194..883963 - 770 Protein_779 RNA polymerase sigma factor SigB -
I6K91_RS04140 883938..884417 - 480 WP_001829903.1 anti-sigma B factor RsbW -
I6K91_RS04145 884419..884745 - 327 WP_002495288.1 anti-sigma factor antagonist -
I6K91_RS04150 884845..885846 - 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
I6K91_RS04155 886191..886553 - 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I6K91_RS04160 886550..886720 - 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
I6K91_RS04165 886807..887955 - 1149 WP_001829972.1 alanine racemase -
I6K91_RS04170 888021..888374 - 354 WP_001829915.1 holo-ACP synthase -
I6K91_RS04175 888422..888931 - 510 WP_001829888.1 PH domain-containing protein -
I6K91_RS04180 888918..890423 - 1506 WP_001829976.1 PH domain-containing protein -
I6K91_RS04185 890416..890895 - 480 WP_001829909.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T192861 WP_001829891.1 NZ_CP070057:c886553-886191 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T192861 NZ_CP092565:c2442512-2442246 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT192861 WP_001829931.1 NZ_CP070057:c886720-886550 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT192861 NZ_CP092565:c2442763-2442512 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References