Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2821645..2822479 Replicon chromosome
Accession NZ_CP070048
Organism Escherichia coli strain FDAARGOS_1290

Toxin (Protein)


Gene name yeeV Uniprot ID A0A8E0IX31
Locus tag I6K20_RS13780 Protein ID WP_000854689.1
Coordinates 2822102..2822479 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0IVP8
Locus tag I6K20_RS13775 Protein ID WP_001285599.1
Coordinates 2821645..2822025 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K20_RS13740 (2817732) 2817732..2818187 + 456 WP_001309747.1 IrmA family protein -
I6K20_RS13745 (2818330) 2818330..2818419 + 90 WP_225385657.1 DUF905 family protein -
I6K20_RS13750 (2818598) 2818598..2819419 + 822 WP_001234555.1 DUF932 domain-containing protein -
I6K20_RS13755 (2819683) 2819683..2820156 + 474 WP_001538139.1 antirestriction protein -
I6K20_RS13760 (2820172) 2820172..2820648 + 477 WP_001186761.1 RadC family protein -
I6K20_RS13765 (2820711) 2820711..2820932 + 222 WP_000692315.1 DUF987 domain-containing protein -
I6K20_RS13770 (2820951) 2820951..2821595 + 645 WP_000086757.1 hypothetical protein -
I6K20_RS13775 (2821645) 2821645..2822025 + 381 WP_001285599.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6K20_RS13780 (2822102) 2822102..2822479 + 378 WP_000854689.1 TA system toxin CbtA family protein Toxin
I6K20_RS13785 (2822476) 2822476..2822964 + 489 WP_000761698.1 DUF5983 family protein -
I6K20_RS13790 (2822981) 2822981..2823178 + 198 WP_000839250.1 DUF957 domain-containing protein -
I6K20_RS13795 (2823263) 2823263..2824108 + 846 WP_001446750.1 DUF4942 domain-containing protein -
I6K20_RS13800 (2824177) 2824177..2824572 + 396 WP_000208381.1 DUF6088 family protein -
I6K20_RS13805 (2824565) 2824565..2825498 + 934 Protein_2724 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
I6K20_RS13810 (2825915) 2825915..2826085 + 171 Protein_2725 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2825930..2826085 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14042.07 Da        Isoelectric Point: 9.1510

>T192843 WP_000854689.1 NZ_CP070048:2822102-2822479 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T192843 NZ_CP092561:c1889050-1888898 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13984.78 Da        Isoelectric Point: 5.0823

>AT192843 WP_001285599.1 NZ_CP070048:2821645-2822025 [Escherichia coli]
MSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLLQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT192843 NZ_CP092561:c1889674-1889075 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References