Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 60112..60848 Replicon plasmid unnamed
Accession NZ_CP070047
Organism Klebsiella pneumoniae strain FDAARGOS_1319

Toxin (Protein)


Gene name tacT Uniprot ID L7SZ15
Locus tag I6K49_RS26035 Protein ID WP_003026803.1
Coordinates 60112..60594 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag I6K49_RS26040 Protein ID WP_003026799.1
Coordinates 60582..60848 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K49_RS26020 55749..56711 + 963 WP_004152113.1 M48 family metalloprotease -
I6K49_RS26025 56799..58053 + 1255 Protein_63 IS3 family transposase -
I6K49_RS26030 58554..59900 - 1347 WP_020314316.1 ISNCY family transposase -
I6K49_RS26035 60112..60594 - 483 WP_003026803.1 GNAT family N-acetyltransferase Toxin
I6K49_RS26040 60582..60848 - 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
I6K49_RS26045 61024..61278 - 255 WP_004152108.1 hypothetical protein -
I6K49_RS26050 61354..61611 - 258 WP_004152107.1 hypothetical protein -
I6K49_RS26055 61660..61863 - 204 WP_004152106.1 hemolysin expression modulator Hha -
I6K49_RS26060 61897..62265 - 369 WP_004152105.1 hypothetical protein -
I6K49_RS26065 62309..62803 - 495 WP_004152104.1 DNA-binding protein -
I6K49_RS26070 62834..63409 - 576 WP_004152103.1 hypothetical protein -
I6K49_RS26075 63397..63666 - 270 WP_004152102.1 hypothetical protein -
I6K49_RS26080 64024..64374 + 351 WP_004152101.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR -
I6K49_RS26085 64424..64786 + 363 WP_004152100.1 arsenite efflux transporter metallochaperone ArsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(D) / qacE / sul1 / blaSHV-1 - 1..215306 215306


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17353.97 Da        Isoelectric Point: 9.5822

>T192822 WP_003026803.1 NZ_CP070047:c60594-60112 [Klebsiella pneumoniae]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

>T192822 NZ_CP092554:c2123877-2123668 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT192822 WP_003026799.1 NZ_CP070047:c60848-60582 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp

>AT192822 NZ_CP092554:c2124182-2123889 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2GNW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References