Detailed information of TA system TA192817

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2913946..2914625
• Replicon: chromosome
• Accession: NZ_CP070046
• Organism: Klebsiella pneumoniae strain FDAARGOS_1319

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: I6K49_RS14045
• Protein ID: WP_065812068.1
• Coordinates: 2914305..2914625 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: I6K49_RS14040
• Protein ID: WP_063444359.1
• Coordinates: 2913946..2914269 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K49_RS14010	2909426..2910301	+	876	WP_065812066.1	GTPase family protein	-
I6K49_RS14015	2910514..2911215	+	702	WP_065812067.1	WYL domain-containing protein	-
I6K49_RS14020	2911221..2911868	+	648	WP_063444361.1	hypothetical protein	-
I6K49_RS14025	2912000..2912461	+	462	WP_063444373.1	hypothetical protein	-
I6K49_RS14030	2912571..2913392	+	822	WP_045341626.1	DUF945 domain-containing protein	-
I6K49_RS14035	2913463..2913933	+	471	WP_063444360.1	DNA repair protein RadC	-
I6K49_RS14040	2913946..2914269	+	324	WP_063444359.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
I6K49_RS14045	2914305..2914625	+	321	WP_065812068.1	TA system toxin CbtA family protein	Toxin
I6K49_RS14050	2914739..2915572	+	834	WP_041162402.1	DUF4942 domain-containing protein	-
I6K49_RS14055	2915983..2917094	+	1112	Protein_2725	IS3 family transposase	-
I6K49_RS14060	2917111..2917299	+	189	Protein_2726	transposase	-
I6K49_RS14065	2917498..2918382	-	885	WP_004192285.1	RES domain-containing protein	-
I6K49_RS14070	2918393..2919065	-	673	Protein_2728	DUF4400 domain-containing protein	-
I6K49_RS14075	2919065..2919331	-	267	WP_004178415.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2891790..2925896	34106

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (12-105)

Antitoxin

• Antitoxin CbeA (7-107)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12008.68 Da
• Isoelectric Point: 6.0604

>T192817 WP_065812068.1 NZ_CP070046:2914305-2914625 [Klebsiella pneumoniae]
MYISAVPATVPVSSRLSPVQVWQQLLTYLLDHHYGLTLNDTPFHDDAAIKEHIDAGITLADAVNFLVERYELVRIDRKGF
SWQEQTPFLTATDILRARRATGLINT

Nucleotide

• Length: 321 bp

>T192817 NZ_CP092552:2723954-2724211 [Staphylococcus aureus]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12082.77 Da
• Isoelectric Point: 6.6314

>AT192817 WP_063444359.1 NZ_CP070046:2913946-2914269 [Klebsiella pneumoniae]
MSITPPHEWGLQSDITPRFGARLVQEGNRLHYLADRAGLTGSFSPIHLQKLDQAFPLFIEQLENMLRVGELNPHQQYHVT
IQLASLTCIADTRGSCGYVYISIYPTQ

Nucleotide

• Length: 324 bp

>AT192817 NZ_CP092552:2723692-2723961 [Staphylococcus aureus]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA