Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2833106..2833622 Replicon chromosome
Accession NZ_CP070046
Organism Klebsiella pneumoniae strain FDAARGOS_1319

Toxin (Protein)


Gene name relE Uniprot ID A0A486Q7B5
Locus tag I6K49_RS13700 Protein ID WP_004192395.1
Coordinates 2833338..2833622 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag I6K49_RS13695 Protein ID WP_004192397.1
Coordinates 2833106..2833348 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K49_RS13680 2829134..2829874 + 741 WP_002886899.1 KDGP aldolase family protein -
I6K49_RS13685 2829941..2831095 + 1155 WP_004178372.1 lactonase family protein -
I6K49_RS13690 2831118..2833028 + 1911 WP_004152270.1 BglG family transcription antiterminator -
I6K49_RS13695 2833106..2833348 + 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6K49_RS13700 2833338..2833622 + 285 WP_004192395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6K49_RS13705 2833626..2834090 - 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I6K49_RS13710 2834398..2836536 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
I6K49_RS13715 2836893..2837636 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
I6K49_RS13720 2837639..2837812 - 174 WP_002886906.1 hypothetical protein -
I6K49_RS13725 2837897..2838205 + 309 WP_004192389.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11184.03 Da        Isoelectric Point: 10.3787

>T192816 WP_004192395.1 NZ_CP070046:2833338-2833622 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQVNKRL

Download         Length: 285 bp

>T192816 NZ_CP092552:c2496330-2496064 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT192816 WP_004192397.1 NZ_CP070046:2833106-2833348 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT192816 NZ_CP092552:c2496587-2496330 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486Q7B5

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References