Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1415275..1415932 Replicon chromosome
Accession NZ_CP070046
Organism Klebsiella pneumoniae strain FDAARGOS_1319

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag I6K49_RS06740 Protein ID WP_002916310.1
Coordinates 1415275..1415685 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag I6K49_RS06745 Protein ID WP_002916312.1
Coordinates 1415666..1415932 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K49_RS06720 1411275..1413008 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
I6K49_RS06725 1413014..1413727 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6K49_RS06730 1413750..1414646 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
I6K49_RS06735 1414747..1415268 + 522 WP_002916308.1 flavodoxin FldB -
I6K49_RS06740 1415275..1415685 - 411 WP_002916310.1 protein YgfX Toxin
I6K49_RS06745 1415666..1415932 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
I6K49_RS06750 1416178..1417161 + 984 WP_065812005.1 tRNA-modifying protein YgfZ -
I6K49_RS06755 1417312..1417971 - 660 WP_002916317.1 hemolysin III family protein -
I6K49_RS06760 1418135..1418446 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
I6K49_RS06765 1418496..1419224 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
I6K49_RS06770 1419343..1420776 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T192810 WP_002916310.1 NZ_CP070046:c1415685-1415275 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T192810 NZ_CP092552:c849219-849031 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT192810 WP_002916312.1 NZ_CP070046:c1415932-1415666 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT192810 NZ_CP092552:c849508-849248 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References