Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1148571..1149042 Replicon chromosome
Accession NZ_CP070041
Organism Escherichia coli strain FDAARGOS_1293

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag I6K23_RS05720 Protein ID WP_001303511.1
Coordinates 1148764..1149042 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag I6K23_RS05715 Protein ID WP_001302048.1
Coordinates 1148571..1148762 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K23_RS05670 (1143820) 1143820..1144038 - 219 WP_000209148.1 DUF4014 family protein -
I6K23_RS05675 (1144071) 1144071..1144283 - 213 WP_000072553.1 hypothetical protein -
I6K23_RS05680 (1144389) 1144389..1144811 - 423 Protein_1130 DUF977 family protein -
I6K23_RS05685 (1144827) 1144827..1145597 - 771 WP_000450998.1 DUF1627 domain-containing protein -
I6K23_RS05690 (1145619) 1145619..1146365 - 747 WP_000788950.1 ATP-binding protein -
I6K23_RS05695 (1146372) 1146372..1147334 - 963 WP_000095673.1 helix-turn-helix domain-containing protein -
I6K23_RS05700 (1147357) 1147357..1147782 - 426 WP_000693943.1 toxin YdaT family protein -
I6K23_RS05705 (1147779) 1147779..1148081 - 303 WP_001556930.1 transcriptional regulator -
I6K23_RS05710 (1148179) 1148179..1148550 + 372 WP_001169687.1 hypothetical protein -
I6K23_RS05715 (1148571) 1148571..1148762 + 192 WP_001302048.1 hypothetical protein Antitoxin
I6K23_RS05720 (1148764) 1148764..1149042 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6K23_RS05725 (1149334) 1149334..1149486 + 153 WP_000380313.1 DUF1391 family protein -
I6K23_RS24830 (1149498) 1149498..1149584 + 87 Protein_1140 hypothetical protein -
I6K23_RS05730 (1149656) 1149656..1150825 + 1170 Protein_1141 IS3-like element ISEc52 family transposase -
I6K23_RS05735 (1150862) 1150862..1151089 + 228 WP_001391547.1 hypothetical protein -
I6K23_RS05740 (1151078) 1151078..1151272 - 195 WP_001295058.1 hypothetical protein -
I6K23_RS05745 (1151848) 1151848..1152036 + 189 WP_000449175.1 cell division inhibition protein DicB -
I6K23_RS05750 (1152033) 1152033..1152221 + 189 WP_000199475.1 DUF1482 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1131173..1159478 28305


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T192753 WP_001303511.1 NZ_CP070041:1148764-1149042 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T192753 NZ_CP092536:2113231-2113333 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT192753 WP_001302048.1 NZ_CP070041:1148571-1148762 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT192753 NZ_CP092536:c2113340-2113195 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References