Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 152422..153332 Replicon plasmid unnamed1
Accession NZ_CP070038
Organism Klebsiella pneumoniae strain FDAARGOS_1322

Toxin (Protein)


Gene name - Uniprot ID R4YBC5
Locus tag I6K52_RS26010 Protein ID WP_004144067.1
Coordinates 152862..153332 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6A8PHD0
Locus tag I6K52_RS26005 Protein ID WP_023287184.1
Coordinates 152422..152865 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K52_RS25975 147461..148627 + 1167 WP_023287153.1 plasmid-partitioning protein SopA -
I6K52_RS25980 148627..149598 + 972 WP_023287152.1 ParB/RepB/Spo0J family plasmid partition protein -
I6K52_RS25985 150449..150677 - 229 Protein_160 type II toxin-antitoxin system Phd/YefM family antitoxin -
I6K52_RS25990 150756..151387 - 632 Protein_161 DUF4113 domain-containing protein -
I6K52_RS25995 151524..152221 + 698 Protein_162 IS1 family transposase -
I6K52_RS26000 152238..152321 + 84 Protein_163 DUF4113 domain-containing protein -
I6K52_RS26005 152422..152865 + 444 WP_023287184.1 DUF2384 domain-containing protein Antitoxin
I6K52_RS26010 152862..153332 + 471 WP_004144067.1 RES family NAD+ phosphorylase Toxin
I6K52_RS26015 153419..154387 + 969 WP_000654811.1 IS5 family transposase -
I6K52_RS26020 154507..154767 - 261 WP_017901409.1 hypothetical protein -
I6K52_RS26025 155340..156113 - 774 Protein_168 transposase -
I6K52_RS26030 156290..157258 + 969 WP_167876146.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..160443 160443
- inside IScluster/Tn - - 151718..157258 5540


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17573.83 Da        Isoelectric Point: 4.5152

>T192739 WP_004144067.1 NZ_CP070038:152862-153332 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T192739 NZ_CP092534:2737059-2737166 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16522.84 Da        Isoelectric Point: 10.3013

>AT192739 WP_023287184.1 NZ_CP070038:152422-152865 [Klebsiella pneumoniae]
MKTFSLSSSPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT192739 NZ_CP092534:c2737006-2736945 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A384IED8

Antitoxin

Source ID Structure
AlphaFold DB A0A6A8PHD0

References