Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3837888..3838545 Replicon chromosome
Accession NZ_CP070037
Organism Klebsiella pneumoniae strain FDAARGOS_1322

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag I6K52_RS18680 Protein ID WP_002916310.1
Coordinates 3838135..3838545 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag I6K52_RS18675 Protein ID WP_002916312.1
Coordinates 3837888..3838154 (+) Length 89 a.a.

Genomic Context

I6K52_RS18660I6K52_RS18665I6K52_RS18675I6K52_RS18680I6K52_RS18690I6K52_RS18695I6K52_RS18700I6K52_RS18650I6K52_RS18655I6K52_RS18670I6K52_RS18685
Location: 3835374..3835685 (312 bp)
Type: Others
Protein ID: WP_004144734.1
Location: 3835849..3836508 (660 bp)
Type: Others
Protein ID: WP_002916317.1
Location: 3837888..3838154 (267 bp)
Type: Antitoxin
Protein ID: WP_002916312.1
Location: 3838135..3838545 (411 bp)
Type: Toxin
Protein ID: WP_002916310.1
Location: 3839174..3840070 (897 bp)
Type: Others
Protein ID: WP_004144729.1
Location: 3840093..3840806 (714 bp)
Type: Others
Protein ID: WP_002916301.1
Location: 3840812..3842545 (1734 bp)
Type: Others
Protein ID: WP_004149758.1
Location: 3833044..3834477 (1434 bp)
Type: Others
Protein ID: WP_002916322.1
Location: 3834596..3835324 (729 bp)
Type: Others
Protein ID: WP_002916321.1
Location: 3836659..3837642 (984 bp)
Type: Others
Protein ID: WP_002916313.1
Location: 3838552..3839073 (522 bp)
Type: Others
Protein ID: WP_002916308.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6K52_RS186503833044..3834477-1434WP_002916322.16-phospho-beta-glucosidase BglA-
I6K52_RS186553834596..3835324-729WP_002916321.1MurR/RpiR family transcriptional regulator-
I6K52_RS186603835374..3835685+312WP_004144734.1N(4)-acetylcytidine aminohydrolase-
I6K52_RS186653835849..3836508+660WP_002916317.1hemolysin III family protein-
I6K52_RS186703836659..3837642-984WP_002916313.1tRNA-modifying protein YgfZ-
I6K52_RS186753837888..3838154+267WP_002916312.1FAD assembly factor SdhEAntitoxin
I6K52_RS186803838135..3838545+411WP_002916310.1protein YgfXToxin
I6K52_RS186853838552..3839073-522WP_002916308.1flavodoxin FldB-
I6K52_RS186903839174..3840070+897WP_004144729.1site-specific tyrosine recombinase XerD-
I6K52_RS186953840093..3840806+714WP_002916301.1bifunctional protein-disulfide isomerase/oxidoreductase DsbC-
I6K52_RS187003840812..3842545+1734WP_004149758.1single-stranded-DNA-specific exonuclease RecJ-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T192730 WP_002916310.1 NZ_CP070037:3838135-3838545 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T192730 NZ_CP092534:c618807-618343 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGTTCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT192730 WP_002916312.1 NZ_CP070037:3837888-3838154 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT192730 NZ_CP092534:c619142-618807 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3GSW7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3GY41

References