Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2470647..2471163 Replicon chromosome
Accession NZ_CP070037
Organism Klebsiella pneumoniae strain FDAARGOS_1322

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag I6K52_RS11985 Protein ID WP_009486548.1
Coordinates 2470647..2470931 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag I6K52_RS11990 Protein ID WP_002886901.1
Coordinates 2470921..2471163 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K52_RS11960 2466043..2466351 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
I6K52_RS11965 2466436..2466609 + 174 WP_004222159.1 hypothetical protein -
I6K52_RS11970 2466612..2467355 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
I6K52_RS11975 2467712..2469850 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
I6K52_RS11980 2470179..2470643 + 465 WP_135726044.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I6K52_RS11985 2470647..2470931 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6K52_RS11990 2470921..2471163 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6K52_RS11995 2471241..2473151 - 1911 WP_004152270.1 BglG family transcription antiterminator -
I6K52_RS12000 2473174..2474328 - 1155 WP_004178372.1 lactonase family protein -
I6K52_RS12005 2474395..2475135 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T192725 WP_009486548.1 NZ_CP070037:c2470931-2470647 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T192725 NZ_CP092533:4030941-4031093 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT192725 WP_002886901.1 NZ_CP070037:c2471163-2470921 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT192725 NZ_CP092533:c4030892-4030835 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References