Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/Xre(antitoxin)
Location 239..740 Replicon plasmid unnamed2
Accession NZ_CP070035
Organism Escherichia coli strain FDAARGOS_1337

Toxin (Protein)


Gene name TsxA Uniprot ID -
Locus tag I6K67_RS23705 Protein ID WP_023225994.1
Coordinates 480..740 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID -
Locus tag I6K67_RS23700 Protein ID WP_000931278.1
Coordinates 239..490 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K67_RS23700 (I6K67_23700) 239..490 - 252 WP_000931278.1 transcriptional regulator Antitoxin
I6K67_RS23705 (I6K67_23705) 480..740 - 261 WP_023225994.1 hypothetical protein Toxin
I6K67_RS23710 (I6K67_23710) 792..1016 - 225 WP_000814383.1 hypothetical protein -
I6K67_RS23715 (I6K67_23715) 1114..1323 - 210 WP_000866037.1 hypothetical protein -
I6K67_RS23720 (I6K67_23720) 1363..1686 - 324 WP_000427402.1 hypothetical protein -
I6K67_RS23725 (I6K67_23725) 2267..2596 - 330 WP_000855121.1 hypothetical protein -
I6K67_RS23730 (I6K67_23730) 3193..3858 + 666 WP_000532148.1 division plane positioning ATPase MipZ -
I6K67_RS23735 (I6K67_23735) 3932..4216 + 285 WP_001162371.1 hypothetical protein -
I6K67_RS23740 (I6K67_23740) 4234..4830 - 597 WP_000125164.1 ProQ/FINO family protein -
I6K67_RS23745 (I6K67_23745) 4980..5102 - 123 WP_223202818.1 Hok/Gef family protein -
I6K67_RS24405 5047..5199 - 153 Protein_10 DUF5431 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..51967 51967


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-37)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9925.43 Da        Isoelectric Point: 10.2412

>T192720 WP_023225994.1 NZ_CP070035:c740-480 [Escherichia coli]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFNEKAFDTIDFSRDGLRENDKDIVFMMIQEMS
EGKNAK

Download         Length: 261 bp

>T192720 NZ_CP092533:2737035-2737142 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9420.81 Da        Isoelectric Point: 9.8120

>AT192720 WP_000931278.1 NZ_CP070035:c490-239 [Escherichia coli]
MLNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN

Download         Length: 252 bp

>AT192720 NZ_CP092533:c2736982-2736921 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References