Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 15240..15775 Replicon plasmid unnamed1
Accession NZ_CP070027
Organism Escherichia coli strain FDAARGOS_1337

Toxin (Protein)


Gene name relE Uniprot ID A0A0K4CX11
Locus tag I6K67_RS23075 Protein ID WP_000222771.1
Coordinates 15240..15527 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T1PXV2
Locus tag I6K67_RS23080 Protein ID WP_001139206.1
Coordinates 15524..15775 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K67_RS23060 (I6K67_23060) 10847..14380 + 3534 WP_136699658.1 autotransporter outer membrane beta-barrel domain-containing protein -
I6K67_RS23065 (I6K67_23065) 14555..14760 - 206 Protein_12 hypothetical protein -
I6K67_RS24355 14759..14872 + 114 Protein_13 alkaline phosphatase -
I6K67_RS23075 (I6K67_23075) 15240..15527 - 288 WP_000222771.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6K67_RS23080 (I6K67_23080) 15524..15775 - 252 WP_001139206.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I6K67_RS23090 (I6K67_23090) 17722..19539 + 1818 Protein_17 helicase -
I6K67_RS23095 (I6K67_23095) 19573..20013 + 441 WP_023352064.1 hypothetical protein -
I6K67_RS23100 (I6K67_23100) 20010..20258 + 249 WP_000747846.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..110044 110044


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11116.17 Da        Isoelectric Point: 10.5833

>T192718 WP_000222771.1 NZ_CP070027:c15527-15240 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKTIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYHLASERMK

Download         Length: 288 bp

>T192718 NZ_CP092533:2130896-2130998 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9171.39 Da        Isoelectric Point: 4.0927

>AT192718 WP_001139206.1 NZ_CP070027:c15775-15524 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYL

Download         Length: 252 bp

>AT192718 NZ_CP092533:c2131036-2130768 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4CX11

Antitoxin

Source ID Structure
AlphaFold DB T1PXV2

References