Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3450692..3451218 Replicon chromosome
Accession NZ_CP070026
Organism Escherichia coli strain FDAARGOS_1337

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag I6K67_RS16790 Protein ID WP_000323025.1
Coordinates 3450692..3450979 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag I6K67_RS16795 Protein ID WP_000534858.1
Coordinates 3450979..3451218 (-) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K67_RS16745 (3445716) 3445716..3445931 - 216 WP_000839590.1 phage lysis protein EssD -
I6K67_RS24120 (3446151) 3446151..3446321 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
I6K67_RS16750 (3446685) 3446685..3446900 - 216 WP_000066484.1 cold shock-like protein CspB -
I6K67_RS16755 (3447201) 3447201..3447413 + 213 WP_000087756.1 cold shock-like protein CspF -
I6K67_RS16760 (3447468) 3447468..3447557 + 90 WP_120795389.1 hypothetical protein -
I6K67_RS16765 (3447835) 3447835..3448587 - 753 WP_001047135.1 antitermination protein -
I6K67_RS16770 (3448601) 3448601..3449650 - 1050 WP_204691517.1 DUF968 domain-containing protein -
I6K67_RS16775 (3449652) 3449652..3449930 - 279 WP_012304870.1 hypothetical protein -
I6K67_RS16780 (3449997) 3449997..3450248 - 252 WP_000980994.1 protein Rem -
I6K67_RS16785 (3450465) 3450465..3450620 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
I6K67_RS16790 (3450692) 3450692..3450979 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
I6K67_RS16795 (3450979) 3450979..3451218 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
I6K67_RS16800 (3451243) 3451243..3451548 + 306 WP_001326990.1 protein YdfV -
I6K67_RS16805 (3451751) 3451751..3452083 + 333 WP_001301033.1 FlxA-like family protein -
I6K67_RS24275 (3452520) 3452520..3452669 - 150 WP_011443592.1 protein YdfW -
I6K67_RS16810 (3452742) 3452742..3453812 - 1071 Protein_3253 ISNCY family transposase -
I6K67_RS16815 (3454602) 3454602..3454889 - 288 Protein_3254 hypothetical protein -
I6K67_RS16820 (3455367) 3455367..3455856 - 490 Protein_3255 class I SAM-dependent methyltransferase -
I6K67_RS16825 (3455853) 3455853..3456104 - 252 Protein_3256 DUF977 family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3435561..3459715 24154


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T192708 WP_000323025.1 NZ_CP070026:c3450979-3450692 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T192708 NZ_CP092532:4147907-4148164 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT192708 WP_000534858.1 NZ_CP070026:c3451218-3450979 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT192708 NZ_CP092532:4148176-4148721 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCGGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References