Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3311248..3311886 Replicon chromosome
Accession NZ_CP070026
Organism Escherichia coli strain FDAARGOS_1337

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag I6K67_RS16105 Protein ID WP_000813794.1
Coordinates 3311248..3311424 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag I6K67_RS16110 Protein ID WP_001270286.1
Coordinates 3311470..3311886 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K67_RS16085 (3306867) 3306867..3308081 - 1215 WP_001326689.1 BenE family transporter YdcO -
I6K67_RS16090 (3308134) 3308134..3308670 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
I6K67_RS16095 (3308743) 3308743..3310704 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
I6K67_RS16100 (3310796) 3310796..3311026 - 231 WP_000494244.1 YncJ family protein -
I6K67_RS16105 (3311248) 3311248..3311424 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
I6K67_RS16110 (3311470) 3311470..3311886 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
I6K67_RS16115 (3311965) 3311965..3313371 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
I6K67_RS16120 (3313616) 3313616..3314761 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
I6K67_RS16125 (3314779) 3314779..3315792 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
I6K67_RS16130 (3315793) 3315793..3316734 + 942 WP_204691506.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T192706 WP_000813794.1 NZ_CP070026:3311248-3311424 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T192706 NZ_CP092532:4031063-4031215 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT192706 WP_001270286.1 NZ_CP070026:3311470-3311886 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT192706 NZ_CP092532:c4031014-4030957 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References