Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4774081..4774738 Replicon chromosome
Accession NZ_CP070020
Organism Klebsiella oxytoca strain FDAARGOS_1333

Toxin (Protein)


Gene name cptA Uniprot ID A0A181X6I0
Locus tag I6K63_RS22170 Protein ID WP_004105559.1
Coordinates 4774081..4774491 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A285B945
Locus tag I6K63_RS22175 Protein ID WP_004105561.1
Coordinates 4774472..4774738 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K63_RS22150 4770058..4771791 - 1734 WP_004105553.1 single-stranded-DNA-specific exonuclease RecJ -
I6K63_RS22155 4771797..4772510 - 714 WP_004105554.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6K63_RS22160 4772533..4773429 - 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
I6K63_RS22165 4773551..4774072 + 522 WP_004105557.1 flavodoxin FldB -
I6K63_RS22170 4774081..4774491 - 411 WP_004105559.1 protein YgfX Toxin
I6K63_RS22175 4774472..4774738 - 267 WP_004105561.1 FAD assembly factor SdhE Antitoxin
I6K63_RS22180 4774982..4775965 + 984 WP_004115279.1 tRNA-modifying protein YgfZ -
I6K63_RS22185 4776093..4776752 - 660 WP_004105569.1 hemolysin III family protein -
I6K63_RS22190 4776914..4777225 - 312 WP_004105571.1 N(4)-acetylcytidine aminohydrolase -
I6K63_RS22195 4777276..4778004 + 729 WP_064352017.1 MurR/RpiR family transcriptional regulator -
I6K63_RS22200 4778125..4779558 + 1434 WP_004105576.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16061.83 Da        Isoelectric Point: 10.9455

>T192690 WP_004105559.1 NZ_CP070020:c4774491-4774081 [Klebsiella oxytoca]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIVGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQD

Download         Length: 411 bp

>T192690 NZ_CP092513:c184288-183977 [Klebsiella quasipneumoniae]
GTGCATGTTATATCACGAGCCCCTTTTGATGAGGCGGCAAGACACTATCCGAATGATGCAGTGGCCATCGATGACACCTA
TCGTGTACTAAAGCGGGTTGTCGCAAAAAAACCGGATGAGCTAAAGCGATACTTTACCAGTCTGGATCGCATGAAATACC
GGGAAAAATGGTGGGTTATCGATATCGGTGGTAATAACCTTAGAATGATGTTTTTTGCTGATTTTGAGCGCGGAAAGATA
TTCGTCAAACACATCACCACCCATGCTGAATATGATCGCTTAACGAAATATTATCGGGAGCACAAAGAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1498

>AT192690 WP_004105561.1 NZ_CP070020:c4774738-4774472 [Klebsiella oxytoca]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT192690 NZ_CP092513:c183980-183564 [Klebsiella quasipneumoniae]
ATGATTTTTAGCGATGCCATTAAAGCGGCGAATGACCTGGCCAGTATTGTCCCTCTGCTGGGTGGCAGCTCGTCCCGCAA
AGATTACGAAGAGGCACTTAAACTCGTTGAATATCTTCTGGAACATGACCCGGACAGCCCGCTGGTTGATATGCTGACTG
CCCGCATTGATGCCTGGGAAGATAACGCGGTGGAATTTGAAGAATTTAATACGCGCATCGAAGCAGGCAAGAACGGTGTT
TCGTTGCTGCGGGTTCTCATGCAGCAACACGGGCTTTCACAGTCCGATTTTGAAAACGAGATAGGCAAAAAATCGCTCGT
CAGCCGGATCCTCAGTGGTGAACGTAGTCTGACCCTCGATCACATGCGGGCGCTGGCAAATCGATTTCAAATCCCGGTCT
CGATGTTTGTTGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A181X6I0

Antitoxin

Source ID Structure
AlphaFold DB A0A285B945

References