Detailed information of TA system TA192679

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 1017806..1018625
• Replicon: chromosome
• Accession: NZ_CP070020
• Organism: Klebsiella oxytoca strain FDAARGOS_1333

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: I6K63_RS04665
• Protein ID: WP_004110819.1
• Coordinates: 1017806..1018063 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: I6K63_RS04670
• Protein ID: WP_023320373.1
• Coordinates: 1018074..1018625 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K63_RS04650	1013578..1014354	-	777	WP_004099223.1	Uxu operon transcriptional regulator	-
I6K63_RS04655	1014490..1015965	-	1476	WP_064370453.1	fructuronate reductase	-
I6K63_RS04660	1016040..1017224	-	1185	WP_004099225.1	mannonate dehydratase	-
I6K63_RS04665	1017806..1018063	+	258	WP_004110819.1	YjhX family toxin	Toxin
I6K63_RS04670	1018074..1018625	+	552	WP_023320373.1	N-acetyltransferase	Antitoxin
I6K63_RS04675	1018643..1020271	+	1629	WP_196558236.1	SAM-dependent methyltransferase	-
I6K63_RS04680	1020435..1021775	-	1341	WP_196558230.1	carbohydrate porin	-
I6K63_RS04685	1021899..1023296	-	1398	WP_077257937.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (17-130)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T192679 WP_004110819.1 NZ_CP070020:1017806-1018063 [Klebsiella oxytoca]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T192679 NZ_CP092510:c4630054-4629743 [Salmonella enterica subsp. enterica serovar Thompson]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20138.98 Da
• Isoelectric Point: 6.8799

>AT192679 WP_023320373.1 NZ_CP070020:1018074-1018625 [Klebsiella oxytoca]
MTNHNFTFHITSERDADDIREVETRAFGFSKEADLVAALLNDESAHPSLSLLAKHNGKAVGHILFTLATFKGESDSPMMH
ILAPLAVVPEYQGVGVGGLLIQRGIEHLKAAGSEAVFVLGHAAYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMLQRLSS
RPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT192679 NZ_CP092510:c4629742-4629452 [Salmonella enterica subsp. enterica serovar Thompson]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2