Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1192952..1193609 Replicon chromosome
Accession NZ_CP070015
Organism Klebsiella pneumoniae strain FDAARGOS_1309

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag I6K39_RS05690 Protein ID WP_002916310.1
Coordinates 1192952..1193362 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag I6K39_RS05695 Protein ID WP_002916312.1
Coordinates 1193343..1193609 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K39_RS05670 1188952..1190685 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
I6K39_RS05675 1190691..1191404 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6K39_RS05680 1191427..1192323 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
I6K39_RS05685 1192424..1192945 + 522 WP_004144730.1 flavodoxin FldB -
I6K39_RS05690 1192952..1193362 - 411 WP_002916310.1 protein YgfX Toxin
I6K39_RS05695 1193343..1193609 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
I6K39_RS05700 1193855..1194838 + 984 WP_020324927.1 tRNA-modifying protein YgfZ -
I6K39_RS05705 1194989..1195648 - 660 WP_002916317.1 hemolysin III family protein -
I6K39_RS05710 1195812..1196123 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
I6K39_RS05715 1196173..1196901 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
I6K39_RS05720 1197020..1198453 + 1434 WP_020324925.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T192668 WP_002916310.1 NZ_CP070015:c1193362-1192952 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T192668 NZ_CP092506:c3088-2744 [Lactiplantibacillus plantarum]
ATGGTAAGCCAAGGTGATATATTTTATGTTAACTTTAATCCAAGCCGTGGTCATGAACAGATGAATAAGCGACCAGCCAT
TGCTCTGAGCAATGATCTAGTCTGTCAGACAAGTAACATGACGATTGTGGCTCCAATTAGCAGTACCAAGCGTAATTTTC
CAATGTATCATCGACTAACTAGTAGTCAAACGGTATATGGAAAAGTATTATTAGATCAAACCATAGCCTTAGATTTACGG
GCAAGACATGTCACTGATGAAACTATTGTCGATCATGTATCGCGTGAAGAACTAGAAGAAATAATCACTTTGTACAAATT
ATTGTTTAGTATTGATGACAAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT192668 WP_002916312.1 NZ_CP070015:c1193609-1193343 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT192668 NZ_CP092506:c3345-3082 [Lactiplantibacillus plantarum]
ATGGAACTTATTAAAGAACAAACACGCTTAGCAAAGTGGGGAAACTCGAAAGCTGCTAGAATTCCTAGCCAAATTATTAA
ACAACTGAAATTAGATGATAACCAAGATATGACAATAACCATTGAAAATGGATCAATTGTTTTAACACCAATAAAAAAGA
ACCCAACCAATATTCACGAACTATTTAAGGATTGGCAAGATGACGGGAAAAGGGATCACGAGCTTGATTGGGGAAAGTCA
GAAGGCAATGAACTTCAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References