Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2628442..2629276 Replicon chromosome
Accession NZ_CP070007
Organism Escherichia coli strain FDAARGOS_1288

Toxin (Protein)


Gene name yeeV Uniprot ID A0A8E0IX31
Locus tag I6K18_RS12625 Protein ID WP_000854689.1
Coordinates 2628442..2628819 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0IVP8
Locus tag I6K18_RS12630 Protein ID WP_001285599.1
Coordinates 2628896..2629276 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K18_RS12595 (2624836) 2624836..2625006 - 171 Protein_2470 IS110 family transposase -
I6K18_RS12600 (2625423) 2625423..2626356 - 934 Protein_2471 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
I6K18_RS12605 (2626349) 2626349..2626744 - 396 WP_000208382.1 DUF6088 family protein -
I6K18_RS12610 (2626813) 2626813..2627658 - 846 WP_001530851.1 DUF4942 domain-containing protein -
I6K18_RS12615 (2627743) 2627743..2627940 - 198 WP_000839250.1 DUF957 domain-containing protein -
I6K18_RS12620 (2627957) 2627957..2628445 - 489 WP_000761698.1 DUF5983 family protein -
I6K18_RS12625 (2628442) 2628442..2628819 - 378 WP_000854689.1 TA system toxin CbtA family protein Toxin
I6K18_RS12630 (2628896) 2628896..2629276 - 381 WP_001285599.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6K18_RS12635 (2629326) 2629326..2629970 - 645 Protein_2478 antitoxin of toxin-antitoxin stability system -
I6K18_RS12645 (2629989) 2629989..2630210 - 222 WP_000692326.1 DUF987 domain-containing protein -
I6K18_RS12650 (2630273) 2630273..2630749 - 477 WP_001702597.1 RadC family protein -
I6K18_RS12655 (2630765) 2630765..2631238 - 474 WP_002431278.1 antirestriction protein -
I6K18_RS12660 (2631502) 2631502..2632323 - 822 WP_001234555.1 DUF932 domain-containing protein -
I6K18_RS28305 (2632502) 2632502..2632591 - 90 WP_225385657.1 DUF905 family protein -
I6K18_RS12670 (2632734) 2632734..2633189 - 456 WP_000581502.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - kpsM / kpsT / ugd / kpsS / kpsC / kpsU / kpsD / kpsE / kpsF 2606543..2631238 24695
- flank IS/Tn - - 2624836..2624991 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14042.07 Da        Isoelectric Point: 9.1510

>T192629 WP_000854689.1 NZ_CP070007:c2628819-2628442 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T192629 NZ_CP092493:374020-374388 [Citrobacter freundii]
ATGACGCTACAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTGACGCCTGGTGTCGCAGG
TATGCCTGACCCCGGTCGTGCGGAAGCGCTGATGTATCGGGTATTGAATCAAATCGAATATGAAGGTGTGACTGACGTGT
GGCTACTGGCGGCAATGCATTTGTTAGCCATTTCCCGTGGGCATATCTTTAATGATGGTAACAAGCGTACTGCGTTATTT
ATTACGTTGCTGTTTTTAAAACGTAATGGGATCGTATTATCTGCAAACCCTGATTTTGTCGCCATGACGGTTGAAGCGGC
AGCAGGACAACTCACGTTAGAACAAATTGCGCATCGTCTGCGCCATTAA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13984.78 Da        Isoelectric Point: 5.0823

>AT192629 WP_001285599.1 NZ_CP070007:c2629276-2628896 [Escherichia coli]
MSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLLQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT192629 NZ_CP092493:373802-374023 [Citrobacter freundii]
ATGCGCACTATGAACTATAGTGAAGCTCGACAAAACCTGGCTGAAGTGCTGGAGAGCGCTGTCACTGGTGTGCCTGTTAC
CATTACGCGCCGTGGTCATAAACCTGCGGTAATCATCAGCGCGGAAGAGTTTGAACGCTATCAGGCCGCCAGACTTGATG
ATGAATTTGCCGACATAATGATGATTCATGGTAATGAAATCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References