Detailed information of TA system TA192625

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1949995..1950607
• Replicon: chromosome
• Accession: NZ_CP070007
• Organism: Escherichia coli strain FDAARGOS_1288

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: U9YXE2
• Locus tag: I6K18_RS09305
• Protein ID: WP_000833473.1
• Coordinates: 1949995..1950180 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: L4IWR9
• Locus tag: I6K18_RS09310
• Protein ID: WP_000499744.1
• Coordinates: 1950197..1950607 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K18_RS09295 (1946827)	1946827..1947978	+	1152	WP_000741501.1	L-threonine dehydrogenase	-
I6K18_RS09300 (1948179)	1948179..1949717	+	1539	WP_001309845.1	aldehyde dehydrogenase AldB	-
I6K18_RS09305 (1949995)	1949995..1950180	+	186	WP_000833473.1	type II toxin-antitoxin system HicA family toxin	Toxin
I6K18_RS09310 (1950197)	1950197..1950607	+	411	WP_000499744.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
I6K18_RS09315 (1950679)	1950679..1952643	-	1965	WP_001026861.1	glycoside hydrolase family 127 protein	-
I6K18_RS09320 (1952654)	1952654..1954054	-	1401	WP_000204802.1	MFS transporter	-
I6K18_RS09325 (1954280)	1954280..1955095	+	816	WP_000891825.1	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6800.89 Da
• Isoelectric Point: 11.7053

>T192625 WP_000833473.1 NZ_CP070007:1949995-1950180 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Nucleotide

• Length: 186 bp

>T192625 NZ_CP092488:c2945575-2944997 [Mycobacterium paraterrae]
ATGAAGCGGCTTGATCTTGTCGTCGGACCCAACGGCGCCGGCAAGTCGACGTTCGTCGAACTTACGCTCGCACCGCTGCT
GCCGGGCAGCCCATTCGTCAACGCCGACGAGATCGCCAAGCAGCGTTGGCCCGATGATCCGGCCGCGCATTCCTACGACG
CCGCGCGGGTCGCAGCGGCGACGCGAACCAAGCTCATCGAGCTGGGCGTGTCGTTCATCGCCGAGACGGTGTTCTCCCAT
CCGTCGAAGGTAGAACTGGTCGACGCCGCTCGGGCAGCGCATTACACCATCGTCTTGCATGTTCTGATCATTCCCGAGGA
GCTTGCGGTCGAGCGCGTCCGGCATCGGGTTGCCGCCGGCGGACACAGCGTCCCCGAGGACAAGATTCGCGAACGCTATC
AACGTCTTTGGGGGTTTGTCGCTGTCGCCATGACCCGTTCTGACTCGGCGACCGTGTATGACAGCAGCGGAATCAAGGGC
CCGCGAATCGTCGCGCAAATCAACGATGGCTTCCTTGTCGGCTCGCCGGCCTGGCCGCGGTGGACACCTGCCGTACTTCG
AGAAGTCTGCAAGGCCTAG

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 15241.15 Da
• Isoelectric Point: 4.5486

>AT192625 WP_000499744.1 NZ_CP070007:1950197-1950607 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Nucleotide

• Length: 411 bp

>AT192625 NZ_CP092488:c2945997-2945572 [Mycobacterium paraterrae]
ATGACGAACATCGCGGACCGAGTTACTCGCGTCGCGGCCGATCTCATGGACAGCGCCGCCGCTGAGGGCGCGCGACAGAG
CCGCTCGGCCAAGCAGCAGCTGGACCACTGGGCCCGCGTGGGACGCGCGGTGTCGACGCAACAGACGGCGGCACGACGAC
GGGTTGAGGCAGCGCTGGCCGGCGAACTGGAACTTCGCGAACTCAGCGTCGAAGAAGGCGTCGTGCTCAACGCTGAGATT
GCGGCCTCCATCCAAGAGAATCTCGCGGCATCGGACTACGGCAAAGTCCTGGCTGCGCGGGGCATCACCACTGTGGCTCT
CGACGACGAAGGTGACATCGTCGAGCACAGGCCTGACGGCTCCTCAATTGTGTTGTCCGCGAACCAACCTCGTCGGAGGA
AGGCGAAGCCTGCGCCGAAGCGATGA

Structures

Toxin

• AlphaFold DB: U9YXE2

Antitoxin

• AlphaFold DB: L4IWR9