192614

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 70246..70805 Replicon plasmid unnamed3
Accession NZ_CP069999
Organism Escherichia coli strain FDAARGOS_1300

Toxin (Protein)


Gene name relE Uniprot ID S1PMX5
Locus tag I6K30_RS26670 Protein ID WP_000421257.1
Coordinates 70246..70521 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C1J8K5
Locus tag I6K30_RS26675 Protein ID WP_001178089.1
Coordinates 70521..70805 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K30_RS26645 (I6K30_26650) 66568..67914 - 1347 WP_001132017.1 protein YagA -
I6K30_RS26650 (I6K30_26655) 68268..68870 + 603 WP_000517698.1 ProQ/FINO family protein -
I6K30_RS26655 (I6K30_26660) 68926..69402 + 477 WP_001401995.1 hypothetical protein -
I6K30_RS26660 (I6K30_26665) 69402..69668 + 267 WP_000627831.1 hypothetical protein -
I6K30_RS26665 (I6K30_26670) 69937..70140 - 204 Protein_78 hypothetical protein -
I6K30_RS26670 (I6K30_26675) 70246..70521 - 276 WP_000421257.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6K30_RS26675 (I6K30_26680) 70521..70805 - 285 WP_001178089.1 ribbon-helix-helix domain-containing protein Antitoxin
I6K30_RS26680 (I6K30_26685) 71713..72744 - 1032 WP_000907880.1 plasmid replication initiator RepA -
I6K30_RS26685 (I6K30_26690) 73445..74086 + 642 WP_000335849.1 transcription termination/antitermination NusG family protein -
I6K30_RS26690 (I6K30_26695) 74227..74889 + 663 WP_000154142.1 hypothetical protein -
I6K30_RS26695 (I6K30_26700) 75156..75776 + 621 WP_000176497.1 DUF1449 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..82270 82270


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10749.45 Da        Isoelectric Point: 9.9324

>T192614 WP_000421257.1 NZ_CP069999:c70521-70246 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T192614 NZ_CP092475:1996703-1996891 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTTACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10474.89 Da        Isoelectric Point: 5.6558

>AT192614 WP_001178089.1 NZ_CP069999:c70805-70521 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp

>AT192614 NZ_CP092475:1996414-1996674 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PMX5

Antitoxin

Source ID Structure
AlphaFold DB A0A731IHA8

References