Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 35014..35573 Replicon plasmid unnamed1
Accession NZ_CP069997
Organism Escherichia coli strain FDAARGOS_1300

Toxin (Protein)


Gene name relE Uniprot ID S1PMX5
Locus tag I6K30_RS25550 Protein ID WP_000421257.1
Coordinates 35014..35289 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C1J8K5
Locus tag I6K30_RS25555 Protein ID WP_001178089.1
Coordinates 35289..35573 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K30_RS25520 (I6K30_25525) 30524..30826 + 303 WP_001245884.1 hypothetical protein -
I6K30_RS25525 (I6K30_25530) 31337..32683 - 1347 WP_001132017.1 protein YagA -
I6K30_RS25530 (I6K30_25535) 33037..33639 + 603 WP_000517698.1 ProQ/FINO family protein -
I6K30_RS25535 (I6K30_25540) 33695..34165 + 471 WP_204641021.1 hypothetical protein -
I6K30_RS25540 (I6K30_25545) 34170..34436 + 267 WP_000627831.1 hypothetical protein -
I6K30_RS25545 (I6K30_25550) 34705..34908 - 204 Protein_50 hypothetical protein -
I6K30_RS25550 (I6K30_25555) 35014..35289 - 276 WP_000421257.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6K30_RS25555 (I6K30_25560) 35289..35573 - 285 WP_001178089.1 ribbon-helix-helix domain-containing protein Antitoxin
I6K30_RS25560 (I6K30_25565) 36481..37511 - 1031 Protein_53 plasmid replication initiator RepA -
I6K30_RS25565 (I6K30_25570) 38212..38853 + 642 WP_000335849.1 transcription termination/antitermination NusG family protein -
I6K30_RS25570 (I6K30_25575) 38994..39656 + 663 WP_000154142.1 hypothetical protein -
I6K30_RS25575 (I6K30_25580) 39923..40543 + 621 WP_000176497.1 DUF1449 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..47037 47037


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10749.45 Da        Isoelectric Point: 9.9324

>T192612 WP_000421257.1 NZ_CP069997:c35289-35014 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T192612 NZ_CP092475:c938358-938263 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10474.89 Da        Isoelectric Point: 5.6558

>AT192612 WP_001178089.1 NZ_CP069997:c35573-35289 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp

>AT192612 NZ_CP092475:938178-938235 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PMX5

Antitoxin

Source ID Structure
AlphaFold DB A0A731IHA8

References