Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3122280..3123081 | Replicon | chromosome |
| Accession | NZ_CP069996 | ||
| Organism | Escherichia coli strain FDAARGOS_1300 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | D8EBK0 |
| Locus tag | I6K30_RS15170 | Protein ID | WP_001094436.1 |
| Coordinates | 3122280..3122657 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | B7MN76 |
| Locus tag | I6K30_RS15175 | Protein ID | WP_015953067.1 |
| Coordinates | 3122704..3123081 (-) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6K30_RS15145 (3118483) | 3118483..3118653 | - | 171 | Protein_2987 | IS110 family transposase | - |
| I6K30_RS15150 (3119050) | 3119050..3120585 | - | 1536 | WP_083574935.1 | EAL domain-containing protein | - |
| I6K30_RS15155 (3120656) | 3120656..3121501 | - | 846 | WP_001280513.1 | DUF4942 domain-containing protein | - |
| I6K30_RS15160 (3121586) | 3121586..3121783 | - | 198 | WP_000839254.1 | DUF957 domain-containing protein | - |
| I6K30_RS15165 (3121795) | 3121795..3122283 | - | 489 | WP_000761714.1 | DUF5983 family protein | - |
| I6K30_RS15170 (3122280) | 3122280..3122657 | - | 378 | WP_001094436.1 | TA system toxin CbtA family protein | Toxin |
| I6K30_RS15175 (3122704) | 3122704..3123081 | - | 378 | WP_015953067.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| I6K30_RS15180 (3123160) | 3123160..3123381 | - | 222 | WP_000692312.1 | DUF987 domain-containing protein | - |
| I6K30_RS15185 (3123450) | 3123450..3123926 | - | 477 | WP_001186756.1 | RadC family protein | - |
| I6K30_RS15190 (3123941) | 3123941..3124426 | - | 486 | WP_000860054.1 | antirestriction protein | - |
| I6K30_RS15195 (3124517) | 3124517..3125335 | - | 819 | WP_001175142.1 | DUF932 domain-containing protein | - |
| I6K30_RS15200 (3125425) | 3125425..3125658 | - | 234 | WP_001278287.1 | DUF905 family protein | - |
| I6K30_RS15205 (3125664) | 3125664..3126341 | - | 678 | WP_001097312.1 | hypothetical protein | - |
| I6K30_RS15210 (3126489) | 3126489..3126944 | - | 456 | Protein_3000 | WYL domain-containing protein | - |
| I6K30_RS15215 (3126986) | 3126986..3127870 | - | 885 | WP_083574934.1 | 50S ribosome-binding GTPase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | rfaE / gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM / kpsM / kpsT / neuD / neuB / neuA / neuC / neuE / kpsS / kpsC / kpsU / kpsD / kpsE / kpsF / papI / papB / papA / papH / papC / papD / papJ / papK / papE / papF / papG | 2981474..3167874 | 186400 | |
| - | flank | IS/Tn | - | - | 3118483..3118587 | 104 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13958.84 Da Isoelectric Point: 6.8603
>T192597 WP_001094436.1 NZ_CP069996:c3122657-3122280 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKQ
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKQ
Download Length: 378 bp
>T192597 NZ_CP092466:4778982-4779260 [Citrobacter portucalensis]
ATGAATAAACTTACTCACTACGATCCCGCGACTGCGCTGGTTGATGATGAAGAAATTGCCGTGTTTATGGCCGATGCCCT
CGAAACAGGCGATGCAGCATACATTGCAAAAGCACTGGGCGTGGTAGCTCGCGCTAAGGGAATGGCGAACATTGCGGCAG
AAACGGGATTATCCCGCGAGCAGCTTTATCGCTCTTTTAGTGAGAAAGGTAACCCGACGCTGAAAACCACCCTTGCAGTG
ATGAAGGTACTCGGCATTGAATTGACACTTAAAAAATAG
ATGAATAAACTTACTCACTACGATCCCGCGACTGCGCTGGTTGATGATGAAGAAATTGCCGTGTTTATGGCCGATGCCCT
CGAAACAGGCGATGCAGCATACATTGCAAAAGCACTGGGCGTGGTAGCTCGCGCTAAGGGAATGGCGAACATTGCGGCAG
AAACGGGATTATCCCGCGAGCAGCTTTATCGCTCTTTTAGTGAGAAAGGTAACCCGACGCTGAAAACCACCCTTGCAGTG
ATGAAGGTACTCGGCATTGAATTGACACTTAAAAAATAG
Antitoxin
Download Length: 126 a.a. Molecular weight: 13766.60 Da Isoelectric Point: 6.2021
>AT192597 WP_015953067.1 NZ_CP069996:c3123081-3122704 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
Download Length: 378 bp
>AT192597 NZ_CP092466:4778672-4778989 [Citrobacter portucalensis]
ATCATGGAAATTCTTCAGACAATGGTTTTCCGGCGTTGGGAGCAAAACCTACGGGACAGGAGAGCTAAAACGCTCATTGC
CACACGCCTTTTTCGTCTGGCTAATGGTTTAGCTGGTGATGTTAAACCTGTTGGGGAAGGCGTCAGCGAAATGCGCATTT
CTTACGGTCCTGGCTACAGGATTTACTTTAAACAGCAAGGTTGCCGCATCATCATTTTGTTATGTGGGGGCGATAAAAGC
TCACAAGCCAACGATATTACTCTTGCAAAAATGCTCGCCCGTACACTGGATTCACAGGAGATCTTCTGCCATGAATAA
ATCATGGAAATTCTTCAGACAATGGTTTTCCGGCGTTGGGAGCAAAACCTACGGGACAGGAGAGCTAAAACGCTCATTGC
CACACGCCTTTTTCGTCTGGCTAATGGTTTAGCTGGTGATGTTAAACCTGTTGGGGAAGGCGTCAGCGAAATGCGCATTT
CTTACGGTCCTGGCTACAGGATTTACTTTAAACAGCAAGGTTGCCGCATCATCATTTTGTTATGTGGGGGCGATAAAAGC
TCACAAGCCAACGATATTACTCTTGCAAAAATGCTCGCCCGTACACTGGATTCACAGGAGATCTTCTGCCATGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E2L1N0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Z3CIS0 |