Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 1842995..1843920 Replicon chromosome
Accession NZ_CP069996
Organism Escherichia coli strain FDAARGOS_1300

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag I6K30_RS09075 Protein ID WP_014640052.1
Coordinates 1842995..1843381 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag I6K30_RS09080 Protein ID WP_024174200.1
Coordinates 1843411..1843920 (-) Length 170 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K30_RS09025 (1838501) 1838501..1839037 + 537 WP_021518223.1 5'-deoxynucleotidase -
I6K30_RS09030 (1839028) 1839028..1839906 + 879 WP_021518222.1 phosphoadenosine phosphosulfate reductase family protein -
I6K30_RS09035 (1839903) 1839903..1840106 + 204 WP_021518221.1 hypothetical protein -
I6K30_RS09040 (1840099) 1840099..1840323 + 225 WP_230151657.1 hypothetical protein -
I6K30_RS09045 (1840336) 1840336..1840890 + 555 WP_021518220.1 ead/Ea22-like family protein -
I6K30_RS09050 (1840892) 1840892..1841083 + 192 WP_001014291.1 hypothetical protein -
I6K30_RS27105 (1841086) 1841086..1841400 + 315 Protein_1792 DUF551 domain-containing protein -
I6K30_RS27110 (1841602) 1841602..1841844 + 243 Protein_1793 DUF551 domain-containing protein -
I6K30_RS09060 (1841844) 1841844..1842416 + 573 WP_001061345.1 3'-5' exonuclease -
I6K30_RS09065 (1842453) 1842453..1842734 + 282 WP_001093916.1 pyocin activator PrtN family protein -
I6K30_RS09070 (1842782) 1842782..1842955 - 174 WP_000390072.1 hypothetical protein -
I6K30_RS09075 (1842995) 1842995..1843381 - 387 WP_014640052.1 hypothetical protein Toxin
I6K30_RS09080 (1843411) 1843411..1843920 - 510 WP_024174200.1 Panacea domain-containing protein Antitoxin
I6K30_RS09085 (1844455) 1844455..1844970 + 516 WP_000416264.1 zinc uptake transcriptional repressor Zur -
I6K30_RS09090 (1845012) 1845012..1845221 - 210 WP_001296638.1 CsbD family protein -
I6K30_RS09095 (1845337) 1845337..1846662 - 1326 WP_001296637.1 MATE family efflux transporter DinF -
I6K30_RS09100 (1846735) 1846735..1847343 - 609 WP_000646078.1 transcriptional repressor LexA -
I6K30_RS09105 (1847453) 1847453..1847821 - 369 WP_000002899.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1801692..1847821 46129


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(6-116)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T192588 WP_014640052.1 NZ_CP069996:c1843381-1842995 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

>T192588 NZ_CP092466:874434-874841 [Citrobacter portucalensis]
GTGGTCCAGTGGCAATCTGATTTACGCGTATCATGGCGCGCGCAGTGGCTTTCACTGCTAATTCATGGGCTGGTCGCGGT
GTTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTTTGCTCTCTCTGGTGGTGTTTGATAGCG
TTCGCAGTCAGCGTCGAATCAACGCCTGTCAGGGTGAGATTCGGCTATTGATGGATGGCCGTCTGCGCTGGCAAGGGCAA
GAGTGGTCTATCGTTAGCGCCCCCTGGATGGTTAAAACAGGTATGATGCTACGCTTGCGATCTGATGCCGGAAAACGTCA
ACATTTGTGGCTGGCAGCAGACAGTATGGATGATGCAGAGTGGCGGGATTTACGACGGTTGATGCTGCAAAAGGCGAAGC
AAGGGTAA

Antitoxin


Download         Length: 170 a.a.        Molecular weight: 19559.39 Da        Isoelectric Point: 5.3338

>AT192588 WP_024174200.1 NZ_CP069996:c1843920-1843411 [Escherichia coli]
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Download         Length: 510 bp

>AT192588 NZ_CP092466:874187-874453 [Citrobacter portucalensis]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGCCGCGGTATGCGCGAGCTGGACATCTCGATCATGCCGTT
TTTTGAACATGAATATGACAGCTTAAGTGACGAAGAAAAACGTATCTTCATCCGTCTGCTAGAATGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCATGGGAAACCAGCTGATGAGCAGCTGGAACAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References