Detailed information of TA system TA192586

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 1321128..1321942
• Replicon: chromosome
• Accession: NZ_CP069996
• Organism: Escherichia coli strain FDAARGOS_1300

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: I6K30_RS06410
• Protein ID: WP_001054376.1
• Coordinates: 1321128..1321385 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: A0A8E0IVE5
• Locus tag: I6K30_RS06415
• Protein ID: WP_001350781.1
• Coordinates: 1321397..1321942 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K30_RS06390 (1316416)	1316416..1317522	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
I6K30_RS06395 (1317587)	1317587..1318567	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
I6K30_RS27050 (1318677)	1318677..1318882	+	206	Protein_1258	HNH endonuclease	-
I6K30_RS06400 (1319150)	1319150..1320390	-	1241	Protein_1259	helicase YjhR	-
I6K30_RS27055 (1320506)	1320506..1320637	+	132	WP_001309182.1	hypothetical protein	-
I6K30_RS06410 (1321128)	1321128..1321385	+	258	WP_001054376.1	YjhX family toxin	Toxin
I6K30_RS06415 (1321397)	1321397..1321942	+	546	WP_001350781.1	N-acetyltransferase	Antitoxin
I6K30_RS06420 (1321998)	1321998..1322744	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
I6K30_RS06425 (1322913)	1322913..1323131	+	219	Protein_1264	hypothetical protein	-
I6K30_RS06430 (1323169)	1323169..1323285	+	117	Protein_1265	VOC family protein	-
I6K30_RS06435 (1323530)	1323530..1324651	+	1122	WP_000010829.1	M42 family metallopeptidase	-
I6K30_RS06440 (1324648)	1324648..1324926	+	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
I6K30_RS06445 (1324938)	1324938..1326251	+	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimC / fimI / fimA / fimE / fimB	1310151..1330166	20015

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T192586 WP_001054376.1 NZ_CP069996:1321128-1321385 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T192586 NZ_CP092461:c4200228-4199806 [Serratia marcescens]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTTTCACTGTTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAGGGCTTTGGCCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGTGCAGGGTGAGCTGCGGCTGCTGGCGGACAGGCGTTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGTTGACGCTGCAGCCGATGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGCATCCGCCGG
CGGGTAACGGCGAGGAACCCTGA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19974.91 Da
• Isoelectric Point: 6.3277

>AT192586 WP_001350781.1 NZ_CP069996:1321397-1321942 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAFIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT192586 NZ_CP092461:c4200475-4200209 [Serratia marcescens]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGTCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGTGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGATGGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Structures

Toxin

• AlphaFold DB: S1PA82