Detailed information of TA system TA192573

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4748846..4750527
• Replicon: chromosome
• Accession: NZ_CP069994
• Organism: Klebsiella pneumoniae strain FDAARGOS_1321

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: I6K51_RS22965
• Protein ID: WP_004146663.1
• Coordinates: 4749610..4750527 (+)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: I6K51_RS22960
• Protein ID: WP_004177809.1
• Coordinates: 4748846..4749604 (+)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K51_RS22945	4744464..4745150	-	687	WP_004151733.1	sel1 repeat family protein	-
I6K51_RS22950	4745612..4747759	-	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
I6K51_RS22955	4748032..4748760	+	729	WP_002885152.1	response regulator transcription factor	-
I6K51_RS22960	4748846..4749604	+	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
I6K51_RS22965	4749610..4750527	+	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
I6K51_RS22970	4750652..4751659	-	1008	WP_009484222.1	carbohydrate kinase family protein	-
I6K51_RS22975	4751734..4752675	-	942	WP_002885156.1	ABC transporter substrate-binding protein	-
I6K51_RS22980	4752706..4753704	-	999	WP_002885172.1	ribose ABC transporter permease	-
I6K51_RS22985	4753701..4755221	-	1521	WP_004210021.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T192573 WP_004146663.1 NZ_CP069994:4749610-4750527 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T192573 NZ_CP092460:809538-809969 [Dickeya fangzhongdai]
GTGGCCCAGTGGCAATGTGATTTGCGTGTATCCTGGCGCATGCAGTTGTTTTCTCTGCTGACGCACGGGTTCCTGGTGCT
GATGATCCTGCTGGCTCCCTGGCCGGACGGCTATGCGCCGCTGTGGCTGGGGTTGGTGACGCTGGTGGTGTTCGGTTTCG
TGCGCAGTCAGCGCATCATCAAGTCGCGTCAGGGGGAAATTTCCCTGCATGGGGAAAACCAACTGCACTGGCAACAGCGT
GACTGGCAGATAGCCCGGCGACCGTGGGTGATGCGCAACGGCGTGTTGCTGTCGTTGCGGGCGACGACCGGCAAAGGGCA
TCAGCGCTTGTGGCTGGCGTCAGACAGTATGGGCAATGAAGAGTGGCGGCTGTTGCGCCAACTGTTGCTGCAGCATCCGC
TGCAGGGCACGGAATCCTCCCGCCATCATTAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT192573 WP_004177809.1 NZ_CP069994:4748846-4749604 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT192573 NZ_CP092460:809291-809557 [Dickeya fangzhongdai]
ATGGACATCAATAACAAATCACGCATTCACTGGGCGTGCAGACGCGGAATGCGTGAACTGGATATTTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACGCTGAGCGACGACGACAAGCAGCATTTCATCCGTCTGTTGCAGTGCGACGATCCCGACT
TGTTCAACTGGCTGATGAACCACGGCGAGCCGGTGGATCCGGAGCTGAAGCGCATGGTTTCCCTTATTCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCAATGTGA

Structures

Toxin

• AlphaFold DB: J2XCI1

Antitoxin

• AlphaFold DB: A6TH05